Unified Total Synthesis of Diverse Meroterpenoids from Ganoderma Applanatum.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01633
Abstract: A unified approach to meroterpenoids applanatumols B, V, W, X, and Y produced by the medicinal fungus Ganoderma applanatum and 2'-epi-spiroapplanatumine O is presented. The key synthetic sequence consists of a tandem anionic ketone allylation/oxy-Cope… read more here.
Keywords: unified total; meroterpenoids ganoderma; diverse meroterpenoids; total synthesis ... See more keywords
Unified Total Syntheses of Benzenoid Cephalotane-Type Norditerpenoids: Cephanolides and Ceforalides.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08803
Abstract: Detailed herein are our synthetic studies toward the preparation of the C18- and C19-benzenoid cephalotane-type norditerpenoids. Guided by chemical network analysis, the core structure of this natural product family was constructed in a concise manner… read more here.
Keywords: cephalotane type; unified total; type norditerpenoids; benzenoid cephalotane ... See more keywords
Unified Total Synthesis of Madangamines A, C, and E.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b00807
Abstract: A stereodivergent strategy for the synthesis of skipped dienes is developed. The method consists of hydroboration of allenes and Migita-Kosugi-Stille coupling, which allows for access to all four possible stereoisomers of the skipped dienes. The… read more here.
Keywords: synthesis madangamines; total synthesis; unified total; synthesis ... See more keywords
Unified Total Synthesis of Pyrroloazocine Indole Alkaloids Sheds Light on Their Biosynthetic Relationship
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b13484
Abstract: The total synthesis of seven members of the lapidilectine and grandilodine family of alkaloids has been accomplished in racemic and enantiopure form without protection/deprotection of functional groups. The two key steps, an 8-endo-dig hydroarylation and… read more here.
Keywords: pyrroloazocine indole; synthesis pyrroloazocine; unified total; indole alkaloids ... See more keywords
Unified total synthesis of the brevianamide alkaloids enabled by chemical investigations into their biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05801k
Abstract: The bicyclo[2.2.2]diazaoctane alkaloids are a vast group of natural products which have been the focus of attention from the scientific community for several decades. This interest stems from their broad range of biological activities, their… read more here.
Keywords: biosynthesis; bicyclo diazaoctane; unified total; synthesis ... See more keywords