UNITED: A Unified Transparent and Efficient Phase I/II Trial Design for Dose Optimization Accounting for Ordinal Graded, Continuous and Mixed Toxicity and Efficacy Endpoints
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DOI: 10.1002/sim.70098
Abstract: A primary objective of oncology dose‐finding trials for novel therapies is to determine an optimal biological dose (OBD) that is both tolerable and therapeutically beneficial for patients in subsequent clinical trials. These new therapeutic agents… read more here.
Keywords: unified transparent; efficacy; efficacy endpoints; toxicity efficacy ... See more keywords