Thymoquinone alleviates renal interstitial fibrosis and kidney dysfunction in rats with unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6376
Abstract: Unilateral ureteral obstruction (UUO) causes severe renal tubulointerstitial fibrosis. Because of many pharmacologic properties of thymoquinone (TQ), in this study, the effects of TQ against kidney fibrosis and dysfunction were investigated in rats with UUO.… read more here.
Keywords: unilateral ureteral; interstitial fibrosis; ureteral obstruction; fibrosis ... See more keywords
Tectorigenin protects against unilateral ureteral obstruction by inhibiting Smad3‐mediated ferroptosis and fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7353
Abstract: Renal tubular epithelial cell (TEC) injury and fibrosis are the key factors of the pathogenesis of chronic kidney disease. Here, we reported that tectorigenin is effectively protected against obstructive nephropathy established by unilateral ureteral obstruction… read more here.
Keywords: smad3; tectorigenin; ferroptosis; treatment ... See more keywords
Urinary kidney injury molecule-1: a novel biomarker to monitor renal function in patients with unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2020 at "International Urology and Nephrology"
DOI: 10.1007/s11255-020-02528-5
Abstract: Purpose This study aimed to investigate the clinical significance of urinary kidney injury molecule-1 (KIM-1) to monitor renal function in patients with obstructive unilateral ureteral calculi. Methods Kidneys of 12 male C57BL/6J mice, as well… read more here.
Keywords: renal function; unilateral ureteral; monitor renal; kidney injury ... See more keywords
Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Investigation"
DOI: 10.1038/s41374-018-0078-8
Abstract: Thioredoxin-interacting protein (TXNIP) is associated with inflammation, tubulointerstitial fibrosis, and oxidative stress in diabetic kidney disease, yet the potential role of TXNIP in nondiabetic renal injury is not well known. This study aimed to investigate… read more here.
Keywords: unilateral ureteral; fibrosis; inflammation; thioredoxin interacting ... See more keywords
FFNT25 ameliorates unilateral ureteral obstruction-induced renal fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Renal Failure"
DOI: 10.1080/0886022x.2019.1612430
Abstract: Abstract Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) patients who progress to end-stage renal disease (ESRD). With the increasing incidence of CKD, it is of importance to develop effective therapies… read more here.
Keywords: unilateral ureteral; ffnt25; fibrosis; renal fibrosis ... See more keywords
Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2088809
Abstract: Abstract Context Protocatechuic aldehyde (PCA) is a natural product that has various benefits for fibrosis. Objective This study evaluated the effects of PCA on renal fibrosis. Materials and methods Epithelial–mesenchymal transition (EMT) was induced by… read more here.
Keywords: renal proximal; proximal tubular; pca; unilateral ureteral ... See more keywords
Ablation of Gadd45β ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15519
Abstract: The growth arrest and DNA damage‐inducible beta (Gadd45β) protein have been associated with various cellular functions, but its role in progressive renal disease is currently unknown. Here, we examined the effect of Gadd45β deletion on… read more here.
Keywords: ureteral obstruction; unilateral ureteral; gadd45; inflammation renal ... See more keywords
Anlotinib Alleviates Renal Fibrosis via Inhibition of the ERK and AKT Signaling Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/1686804
Abstract: Purpose We examined whether anlotinib can attenuate folic acid-induced and unilateral ureteral obstruction-induced renal fibrosis and explored the underlying antifibrotic mechanism. Materials and Methods We have evaluated the effects of anlotinib on folic acid-induced and… read more here.
Keywords: renal fibrosis; acid induced; folic acid; unilateral ureteral ... See more keywords
Exogenous H2S Inhibits Autophagy in Unilateral Ureteral Obstruction Mouse Renal Tubule Cells by Regulating the ROS-AMPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000493824
Abstract: Background/Aims: The induction of excessive autophagy by increased levels of oxidative stress is one of the main mechanisms underlying unilateral ureteral obstruction (UUO)-induced vascular endothelial cell dysfunction. Hydrogen sulfide (H2S) has been shown to have… read more here.
Keywords: ureteral obstruction; unilateral ureteral; exogenous h2s; ros ampk ... See more keywords
Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction
Sign Up to like & getrecommendations! Published in 2019 at "Nephron"
DOI: 10.1159/000497489
Abstract: Background: The progression of chronic renal failure in patients with unilateral renal injury is associated with loss of function in the contralateral kidney, but the molecular mechanism remains unclear. The activation of mineralocorticoid receptor (MR)… read more here.
Keywords: unilateral ureteral; ureteral obstruction; pyroptosis; contralateral kidneys ... See more keywords
Alteration of N6-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "Epigenomics"
DOI: 10.2217/epi-2020-0126
Abstract: Aim: To reveal the alterations of N6-methyladenosine (m6A) epitranscriptome profile in kidney after unilateral ureteral obstruction in mice. Materials & methods: Total renal m6A and expressions of methyltransferases and demethylases were detected by colorimetric quantification… read more here.
Keywords: unilateral ureteral; obstructive nephropathy; alteration methyladenosine; epitranscriptome profile ... See more keywords