Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102895
Abstract: Summary The mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane that is involved in various cellular processes. The components of this uniporter, including the pore-forming membrane subunit MCU and the modulatory… read more here.
Keywords: uniporter; uptake regulation; characterization mitochondrial; ca2 uptake ... See more keywords
Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death
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DOI: 10.1155/2019/1681254
Abstract: Neurodegenerative diseases are a large and heterogeneous group of disorders characterized by selective and progressive death of specific neuronal subtypes. In most of the cases, the pathophysiology is still poorly understood, although a number of… read more here.
Keywords: uniporter; overexpression; neuronal death; ca2 ... See more keywords
From the Identification to the Dissection of the Physiological Role of the Mitochondrial Calcium Uniporter: An Ongoing Story
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DOI: 10.3390/biom11060786
Abstract: The notion of mitochondria being involved in the decoding and shaping of intracellular Ca2+ signals has been circulating since the end of the 19th century. Despite that, the molecular identity of the channel that mediates… read more here.
Keywords: uniporter; physiological role; physiology; ca2 ... See more keywords