Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability
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DOI: 10.1080/14728222.2021.1864321
Abstract: ABSTRACT Introduction: Translesion synthesis (TLS) is a DNA damage tolerance (DDT) mechanism that employs error-prone polymerases to bypass replication blocking DNA lesions, contributing to a gain in mutagenesis and chemo-resistance. However, recent findings illustrate an… read more here.
Keywords: tls; translesion synthesis; synthesis tls; cancer ... See more keywords