A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
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DOI: 10.1021/acs.jmedchem.0c01174
Abstract: STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the role of STK17B in normal and disease pathology is poorly defined. Here,… read more here.
Keywords: loop conformation; stk17b; unique loop; dark kinase ... See more keywords