Topologically Unique Molecular Nanocarbons.
Sign Up to like & getrecommendations! Published in 2019 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.9b00402
Abstract: As new forms of carbon are unearthed, they invariably transform the scientific landscape. Numerous researchers have been inspired to discover the unique characteristics of these fascinating materials, consistently leading to the development of important technological… read more here.
Keywords: topologically unique; carbon; molecular nanocarbons; unique molecular ... See more keywords
Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.7b00505
Abstract: Schizophrenia is associated with core deficits in cognitive abilities and impaired functioning of the newly evolved prefrontal association cortex (PFC). In particular, neuropathological studies of schizophrenia have found selective atrophy of the pyramidal cell microcircuits… read more here.
Keywords: molecular regulation; regulation higher; layer iii; unique molecular ... See more keywords
Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71323-0
Abstract: The attachment of unique molecular identifiers (UMIs) to RNA molecules prior to PCR amplification and sequencing, makes it possible to amplify libraries to a level that is sufficient to identify rare molecules, whilst simultaneously eliminating… read more here.
Keywords: small rna; identifiers umis; rna; insufficiently complex ... See more keywords
Non-invasive Detection of Unique Molecular Signatures in Laser-Induced Retinal Injuries.
Sign Up to like & getrecommendations! Published in 2018 at "Military medicine"
DOI: 10.1093/milmed/usx213
Abstract: Unintentional laser exposure is an increasing concern in many operational environments. Determining whether a laser exposure event caused a retinal injury currently requires medical expertise and specialized equipment that are not always readily available. The… read more here.
Keywords: laser; invasive detection; non invasive; unique molecular ... See more keywords
Accurate estimation of molecular counts from amplicon sequence data with unique molecular identifiers
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.06.12.495839
Abstract: Motivation Amplicon sequencing is widely applied to explore heterogeneity and rare variants in genetic populations. Resolving true biological variants and quantifying their abundance is crucial for downstream analyses, but measured abundances are distorted by stochasticity… read more here.
Keywords: abundance; amplicon sequence; estimation; sequence data ... See more keywords
Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Case Reports"
DOI: 10.1136/bcr-2018-228153
Abstract: Paediatric high-grade gliomas, including glioblastoma and anaplastic astrocytoma, make up 8%–12% of paediatric central nervous system tumours 1 and have poor prognosis, with 2-year survival less than 30% 2 and overall survival less than 10%.… read more here.
Keywords: atypical anaplastic; astrocytoma unique; anaplastic astrocytoma; unique molecular ... See more keywords
Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-07814-8
Abstract: Background Our objective was to assess whether modifications to a customized targeted RNA sequencing (RNAseq) assay to include unique molecular identifiers (UMIs) that collapse read counts to their source mRNA counts would improve quantification of… read more here.
Keywords: ffpe samples; set4 assay; rnaseq assay; unique molecular ... See more keywords
Incorporation of unique molecular identifiers in TruSeq adapters improves the accuracy of quantitative sequencing.
Sign Up to like & getrecommendations! Published in 2017 at "BioTechniques"
DOI: 10.2144/000114608
Abstract: Quantitative analysis of next-generation sequencing (NGS) data requires discriminating duplicate reads generated by PCR from identical molecules that are of unique origin. Typically, PCR duplicates are identified as sequence reads that align to the same… read more here.
Keywords: sequencing incorporation; molecular identifiers; unique molecular; incorporation unique ... See more keywords
Comparative functional genomics identifies unique molecular features of EPSCs
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201608
Abstract: The authors provide a comprehensive resource on proteomics, transcriptomic, and epigenetic level details of EPSCs to shed light on possible molecular pathways regulating their expanded pluripotency potential. Extended pluripotent or expanded potential stem cells (EPSCs)… read more here.
Keywords: comparative functional; identifies unique; genomics identifies; functional genomics ... See more keywords
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2017.00024
Abstract: The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for tumor growth and progression. Cells of both the innate and adaptive immune system, in particular tumor-associated macrophages (TAMs) and T cells,… read more here.
Keywords: microenvironment; host cells; unique molecular; ovarian cancer ... See more keywords
Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121732
Abstract: The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER). Cosmc helps C1GALT1 to fold correctly and maintain activity. It also participates in… read more here.
Keywords: chaperone cosmc; chaperone; cosmc; regulation ... See more keywords