Unique transcriptional signatures correlate with behavioral and psychological symptom domains in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Translational Psychiatry"
DOI: 10.1038/s41398-024-02878-z
Abstract: Despite the significant burden, cost, and worse prognosis of Alzheimer’s disease (AD) with behavioral and psychological symptoms of dementia (BPSD), little is known about the molecular causes of these symptoms. Using antemortem assessments of BPSD… read more here.
Keywords: alzheimer disease; domain; agitation; unique transcriptional ... See more keywords
Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3464
Abstract: Missense mutations in the DNA binding domain of p53 are characterized as structural or contact mutations based on their effect on the conformation of the protein. These mutations show gain-of-function activities, such as promoting increased… read more here.
Keywords: profiles underlie; p53 mutants; underlie osteosarcomagenesis; transcriptional profiles ... See more keywords