Towards a Digital Bioprocess Replica: Computational Approaches in Biopharmaceutical Development and Manufacturing.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2020.05.008
Abstract: Quantitative unit operation models for the optimization and refinement of modern late-stage biopharmaceutical drug manufacturing processes have recently attracted increasing attention. The supplementary benefits of these models include increased process robustness and control in combination… read more here.
Keywords: bioprocess; digital bioprocess; unit operation; manufacturing ... See more keywords
Holistic Design of Experiments Using an Integrated Process Model
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DOI: 10.3390/bioengineering9110643
Abstract: Statistical experimental designs such as factorial, optimal, or definitive screening designs represent the state of the art in biopharmaceutical process characterization. However, such methods alone do not leverage the fact that processes operate as a… read more here.
Keywords: design; process model; integrated process; model ... See more keywords