Site-Specific Dinitrophenylation of Single-Chain Antibody Fragments for Redirecting a Universal CAR-T Cell against Cancer Antigens.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167513
Abstract: We have previously developed a universal chimeric antigen receptor (CAR), which recognizes dinitrophenyl (DNP) and can redirect T and NK cells to target cancer and HIV antigens using DNP-conjugated antibodies as adaptor molecules. However, the… read more here.
Keywords: single chain; site specific; universal car; dnp ... See more keywords
A Universal CAR-NK Cell Targeting Various Epitopes of HIV-1 gp160.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00537
Abstract: Engineering T cells and natural killer (NK) cells with anti-HIV chimeric antigen receptors (CAR) has emerged as a promising strategy to eradicate HIV-infected cells. However, current anti-HIV CARs are limited by targeting a single epitope… read more here.
Keywords: car cell; universal car; cell; car ... See more keywords
Evaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AML
Sign Up to like & getrecommendations! Published in 2021 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.1945804
Abstract: ABSTRACT Chimeric antigen receptor T cells (CAR-T) targeting CD19 have achieved significant success in patients with B cell malignancies. To date, implementation of CAR-T in other indications remains challenging due to the lack of truly… read more here.
Keywords: targeting cd123; costimulation; aml; universal car ... See more keywords
Abstract 1787: Design of bispecific adapters for universal CAR T cell therapies of solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1787
Abstract: Recent success in the use of chimeric antigen receptor (CAR) T cell therapies to treat hematologic cancers has encouraged the exploration of CAR T cell technologies to treat solid tumors. For establishment of a productive… read more here.
Keywords: cell; car; bispecific; universal car ... See more keywords
Abstract 4798: In vivo generation of universal CAR T cells for targeting heterologous antigens in solid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4798
Abstract: The successes of autologous CAR T cell therapies in treating hematologic malignancies has spurred interest in applying the same approaches for treating solid tumors. However, challenges associated with antigen heterogeneity, CAR T cell exhaustion, cytokine… read more here.
Keywords: cancer; solid tumors; universal car; car ... See more keywords
Universal CAR T Cells Treat Leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2017-023
Abstract: Two infants with relapsed, refractory B-cell acute lymphoblastic leukemia went into complete remission after being treated with CD19-targeting CAR T cells derived from an unmatched donor. The study is the first to demonstrate that a… read more here.
Keywords: treat leukemia; cells treat; universal car; car cells ... See more keywords
Universal CAR 2.0 to overcome current limitations in CAR therapy
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1383894
Abstract: Chimeric antigen receptor (CAR) T cell therapy has effectively complemented the treatment of advanced relapsed and refractory hematological cancers. The remarkable achievements of CD19- and BCMA-CAR T therapies have raised high expectations within the fields… read more here.
Keywords: therapy; universal car; car overcome; car ... See more keywords