Quantitative Control of Gene-Engineered T cell Activity Through Covalent Attachment of Targeting Ligands to a Universal Immune Receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11622
Abstract: Universal immune receptors represent a rapidly emerging form of adoptive T cell therapy with the potential to overcome safety and antigen escape challenges faced by conventional chimeric antigen receptor (CAR) T cell therapy. By decoupling… read more here.
Keywords: targeting ligands; universal immune; antigen; receptor ... See more keywords
The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00176
Abstract: Chimeric antigen receptor (CAR) T cells have shown great success in the treatment of CD19+ hematological malignancies, leading to their recent approval by the FDA as a new cancer treatment modality. However, their broad use… read more here.
Keywords: immune receptors; universal immune; antigen; receptor ... See more keywords