Characterization of an unknown impurity in doxofylline using LC–MS and NMR
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.03.025
Abstract: &NA; During quality control of doxofylline, a novel impurity was detected, which was above the identification threshold defined by ICH. First, a liquid chromatographic method compatible with mass spectrometric (MS) detection was developed. Based on… read more here.
Keywords: novel impurity; impurity doxofylline; unknown impurity; characterization unknown ... See more keywords
Ampicillin sodium: Isolation, identification and synthesis of the last unknown impurity after 60 years of clinical use.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113584
Abstract: Ampicillin, discovered in 1958, was the first broad spectrum semisynthetic penicillin introduced into the market. Despite its wide use not all the impurities have been identified to date. Herein, the last unknown impurity present in… read more here.
Keywords: last unknown; ampicillin sodium; use; unknown impurity ... See more keywords
Detection and Characterization of an Unknown Impurity in Levothyroxine Oral Solution Product: Implications for Formulation Development and Storage.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.09.054
Abstract: An existing USP(2010) impurity method for levothyroxine drug substance was modified to expand its applicability for the analysis of levothyroxine oral solution (OS) formulation while achieving desirable resolution between the components of OS formulation. When… read more here.
Keywords: oral solution; levothyroxine oral; formulation; unknown impurity ... See more keywords