Multi-omic analysis in carcinoma of unknown primary (CUP): therapeutic impact of knowing the unknown.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13293
Abstract: Carcinoma of unknown primary (CUP) is a difficult-to-manage malignancy. Multi-omic profiles and treatment outcome versus degree of precision matching was assessed. Tumors underwent next-generation sequencing (NGS) [tissue and/or blood-derived cell-free DNA (cfDNA)]. Selected patients had… read more here.
Keywords: cup; unknown primary; multi omic; analysis ... See more keywords
Long‐term results of elective mucosal irradiation for head and neck cancer of unknown primary in Chinese population: The EMICUP study
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DOI: 10.1002/cam4.2856
Abstract: Controversy still exists regarding the volume of radiation for head and neck cancer of unknown primary (HNCUP). Theoretically, elective mucosal irradiation (EMI) should achieve a balance between survival and toxicity. This prospective study was conducted… read more here.
Keywords: neck cancer; elective mucosal; cancer unknown; unknown primary ... See more keywords
A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years
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DOI: 10.1002/cam4.4960
Abstract: The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors. read more here.
Keywords: unfavorable cancer; unknown primary; generational comparison; comparison unfavorable ... See more keywords
Clinicopathological, molecular and prognostic characteristics of cancer of unknown primary in China: An analysis of 1420 cases
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DOI: 10.1002/cam4.4973
Abstract: Cancer of unknown primary (CUP) is defined the presence of metastatic disease without an identified primary site. An unidentifiable primary site of cancer creates significant challenges for treatment selection. We aimed to describe the clinicopathological,… read more here.
Keywords: molecular prognostic; unknown primary; cancer unknown; clinicopathological molecular ... See more keywords
Prognostic impact of copy number alterations and tumor mutational burden in carcinoma of unknown primary
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DOI: 10.1002/gcc.23047
Abstract: Chromosomal aberrations are known to drive metastatic spread, but their profile is still elusive in carcinoma of unknown primary (CUP). Therefore, the aim of this study was to characterize the chromosomal aberration pattern in CUP… read more here.
Keywords: prognostic impact; unknown primary; tumor mutational; mutational burden ... See more keywords
Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi-centre study.
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DOI: 10.1002/ijc.34020
Abstract: Based on molecular evidence that melanomas with unknown primary (MUPs) arise from the skin, we hypothesised that sites of MUPs are disproportionately on trunk and lower limbs, sites that are not readily visible to patients… read more here.
Keywords: stage iii; cutaneous sites; melanomas unknown; unknown primary ... See more keywords
Melanoma of unknown primary
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DOI: 10.1002/jso.25302
Abstract: Formally described in the 1960s, melanoma of unknown primary (MUP) is characterized by the finding of metastatic melanoma within the lymph nodes, subcutaneous tissues, and other distant sites without an evident primary lesion. The most… read more here.
Keywords: oncology; unknown primary; melanoma unknown; etiology ... See more keywords
Psychological distress, understanding of cancer and illness uncertainty in patients with Cancer of Unknown Primary
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DOI: 10.1002/pon.5990
Abstract: Patients diagnosed with Cancer of Unknown Primary (CUP) experience high levels of psychological distress and report poor understanding of their cancer. We aimed to investigate: (1) if CUP patients with poorer understanding of their cancer… read more here.
Keywords: understanding cancer; unknown primary; psychological distress; cancer unknown ... See more keywords
Melanoma of unknown primary: a case series
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DOI: 10.1007/s11845-022-02951-w
Abstract: Melanoma of unknown primary (MUP) was originally defined in 1963 by Dasgupta et al. as melanoma in the subcutaneous tissue, lymph nodes or visceral organs without the presence of cutaneous, ocular or mucosal primary [1].… read more here.
Keywords: unknown primary; melanoma unknown; subcutaneous tissue; melanoma ... See more keywords
Comparative genomic characterization of melanoma of known and unknown primary
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DOI: 10.1007/s12094-021-02629-2
Abstract: This study aims to genomically characterize melanoma of unknown primary (MUP) in comparison to melanomas of cutaneous primary (MCP). Eligible cases were collected from the MSK-IMPACT™ Clinical Sequencing Cohort published in the cBioPortal database. Genomic… read more here.
Keywords: melanoma known; characterization melanoma; genomic characterization; known unknown ... See more keywords
Head and neck carcinoma of unknown primary.
Sign Up to like & getrecommendations! Published in 2019 at "European annals of otorhinolaryngology, head and neck diseases"
DOI: 10.1016/j.anorl.2019.04.002
Abstract: In adult cervicofacial pathology, carcinoma of unknown primary is defined as lymph-node metastasis the anatomic origin of which is not known at the time of initial management. It constitutes up to 5% of head and… read more here.
Keywords: carcinoma unknown; carcinoma; pathology; unknown primary ... See more keywords