5‐HT7 Receptor Antagonists with an Unprecedented Selectivity Profile
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DOI: 10.1002/cmdc.201800026
Abstract: Selective leads: In this study, we generated a new series of serotonin 5-HT7 receptor antagonists. Their synthesis, structure-activity relationships, and selectivity profiles are reported. This series includes 5-HT7 antagonists with unprecedented high selectivity for the… read more here.
Keywords: antagonists unprecedented; ht7 receptor; unprecedented selectivity; receptor antagonists ... See more keywords
Diazepine Agonists of the 5‑HT2C Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352)
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DOI: 10.1021/acs.jmedchem.4c02923
Abstract: The clinical development of novel 5-HT2C receptor (5-HT2CR) therapies has been limited due to concerns over lack of selectivity and potential for off-target effects. Here, we report that the introduction of a secondary amide substituent… read more here.
Keywords: unprecedented selectivity; diazepine agonists; bexicaserin; selectivity ... See more keywords
Unprecedented selectivity for homologous lectin targets: differential targeting of the viral receptors L-SIGN and DC-SIGN
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DOI: 10.1039/d4sc02980a
Abstract: DC-SIGN (CD209) and L-SIGN (CD209L) are two C-type lectin receptors (CLRs) that facilitate SARS-CoV-2 infections as viral co-receptors. SARS-CoV-2 manipulates both DC-SIGN and L-SIGN for enhanced infection, leading to interest in developing receptor antagonists. Despite… read more here.
Keywords: sars cov; unprecedented selectivity; sign; selectivity ... See more keywords