Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4720-8
Abstract: RationaleSaikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties.ObjectivesThe present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD.MethodsBehavioural tests including… read more here.
Keywords: hippocampal neurogenesis; unpredictable chronic; chronic mild; hpa axis ... See more keywords
The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05849-0
Abstract: Rationale The prevalence of depression is ever-increasing throughout the population. However, available treatments are ineffective in around one-third of patients and there is a need for more effective and safer drugs. Objectives The antidepressant-like and… read more here.
Keywords: agonists f15599; f15599 f13714; unpredictable chronic; like properties ... See more keywords
Association between increased inflammatory cytokine expression in the lateral habenular nucleus and depressive-like behavior induced by unpredictable chronic stress in rats
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113964
Abstract: Depression induced by unpredictable chronic stress (UCS) has been widely studied using animal models. However, its underlying pathological mechanisms remain unclear. Increased inflammatory cytokines (ICs) in the central nervous system (CNS) are closely related to… read more here.
Keywords: like behavior; expression; induced unpredictable; depressive like ... See more keywords
Improvement of penile neurogenic and endothelial relaxant responses by chronic administration of resveratrol in rabbits exposed to unpredictable chronic mild stress
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Impotence Research"
DOI: 10.1038/s41443-018-0016-8
Abstract: Chronic stress is an important public health problem known as a risk factor for depression, cognitive deficits, and also erectile dysfunction (ED). Resveratrol, a plant polyphenol, was reported to activate constitutive endothelial nitric oxide synthase… read more here.
Keywords: resveratrol; endothelium dependent; stress; chronic mild ... See more keywords
Telmisartan Activates PPARδ to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14265-4
Abstract: Major depression is a common mental disorder that has been established to be associated with a decrease in serotonin and/or serotonin transporters in the brain. Peroxisome proliferator-activated receptor δ (PPARδ) has been introduced as a… read more here.
Keywords: ppar; depression; telmisartan; stress ... See more keywords
Preventive impacts of vitamin C on memory damage caused by unpredictable chronic mild stress in relation to biochemical parameters in the hippocampus of male rats.
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2022.2145423
Abstract: KEY POINTS Memory and learning impairments were induced by unpredictable chronic mild stress (UCMS)Vitamin C could prevent cognitive impairments caused by UCMS in rats by attenuation of oxidative stress in the brain. read more here.
Keywords: stress; chronic mild; mild stress; unpredictable chronic ... See more keywords
Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1171646
Abstract: Introduction: This study aims to further characterize cannabidiol’s pharmacological and molecular profile as an antidepressant. Methods: Effects of cannabidiol (CBD), alone or combined with sertraline (STR), were evaluated in male CD1 mice (n = 48)… read more here.
Keywords: mild stress; unpredictable chronic; model; chronic mild ... See more keywords
Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24183396
Abstract: Treatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of Dipterocarpus alatus leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced… read more here.
Keywords: dipterocarpus alatus; ethanol extract; extract dipterocarpus; chronic mild ... See more keywords