Unraveling the Molecular Landscape of SCN1A Gene Knockout in Cerebral Organoids: A Multiomics Approach Utilizing Proteomics, Lipidomics, and Transcriptomics
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c05039
Abstract: This study investigates the impact of sodium channel protein type 1 subunit alpha (SCN1A) gene knockout (SCN1A KO) on brain development and function using cerebral organoids coupled with a multiomics approach. From comprehensive omics analyses,… read more here.
Keywords: unraveling molecular; scn1a gene; gene knockout; multiomics approach ... See more keywords
Unraveling the Molecular Details of the Complete Mechanism That Governs the Synthesis of Prostaglandin G2 Catalyzed by Cyclooxygenase-2
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b03575
Abstract: Cyclooxygenase-2 (COX-2) is the key enzyme involved in the synthesis pathway of prostaglandin G2 (PGG2) by transformation of arachidonic acid (AA). Although COX-2 is one of the principal pharmacolo... read more here.
Keywords: prostaglandin; cyclooxygenase; synthesis; unraveling molecular ... See more keywords
Unraveling the molecular basis of membrane-associated release of coxsackievirus B3
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-92289-x
Abstract: Coxsackievirus B3 (CVB3), a member of the Enterovirus genus within the Picornaviridae family, has emerged as a key model for studying viral evolution and pathogenesis. Although traditionally considered obligate lytic viruses, recent research reveals that… read more here.
Keywords: membrane associated; unraveling molecular; release; culture ... See more keywords
Unraveling the molecular and growth mechanism of colloidal black In2O3−x
Sign Up to like & getrecommendations! Published in 2024 at "Nanoscale"
DOI: 10.1039/d3nr05035a
Abstract: Black metal oxides with varying concentrations of O-vacancies display enhanced optical and catalytic properties. However, direct solution syntheses of this class of materials have been limited despite being highly advantageous given the different synthetic handles… read more here.
Keywords: growth mechanism; in2o3; unraveling molecular; molecular growth ... See more keywords
Unraveling molecular mechanisms of β-glucuronidase inhibition by flavonoids from Centaurea scoparia: integrated in silico and in vitro insights
Sign Up to like & getrecommendations! Published in 2024 at "New Journal of Chemistry"
DOI: 10.1039/d4nj02393e
Abstract: Investigating the detailed molecular mechanisms of β-glucuronidase inhibition is critical for pioneering new therapeutic solutions and driving progress in pharmaceutical research. read more here.
Keywords: glucuronidase inhibition; unraveling molecular; inhibition flavonoids; molecular mechanisms ... See more keywords
Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk
Sign Up to like & getrecommendations! Published in 2024 at "Food and Agricultural Immunology"
DOI: 10.1080/09540105.2024.2434457
Abstract: ABSTRACT Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group of neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. These conditions arise due to the gradual… read more here.
Keywords: unraveling molecular; diet unraveling; neurodegenerative diseases; molecular pathways ... See more keywords
Neurotransmitter Transporters—Unraveling Molecular Mechanisms and Therapeutic Opportunities
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.70240
Abstract: Neurotransmitter transporters are essential regulators of synaptic neurotransmission, maintaining the delicate balance of neurotransmitters in the central and peripheral nervous systems. Dysfunction of these transporters is linked to a wide range of neurological and psychiatric… read more here.
Keywords: neurotransmitter transporters; unraveling molecular; transporters unraveling; molecular mechanisms ... See more keywords
Unraveling the molecular and cellular mechanisms of stretch marks
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.12974
Abstract: Striae distensae, commonly known as stretch marks, are cutaneous lesions that accompany the hormonal upheavals of the major stages of life: puberty and pregnancy. Stretch marks occur in 90% of women, and they appear as… read more here.
Keywords: molecular cellular; cellular mechanisms; unraveling molecular; stretch marks ... See more keywords
Unraveling the Molecular Basis of Extracranial Glioblastoma Metastasis: A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2025 at "Neuropathology"
DOI: 10.1111/neup.70025
Abstract: Glioblastoma (GB), IDH‐wildtype (IDH‐wt), is the most prevalent primary malignant brain neoplasm in adults. Despite adjuvant therapy, the prognosis for these tumors remains dismal, with a median survival of around 15–18 months. Although rare, extracranial metastases… read more here.
Keywords: unraveling molecular; glioblastoma; case; metastasis ... See more keywords
Unraveling the molecular mechanisms underlying flat stem formation in Atractylodes lancea in response to phytoplasmas
Sign Up to like & getrecommendations! Published in 2025 at "Physiologia Plantarum"
DOI: 10.1111/ppl.70192
Abstract: For centuries, the herb Atractylodes lancea (Thunb.) has been revered for its pharmacological properties, particularly its efficacy in combating spleen and stomach ailments. However, prolonged artificial cultivation of A. lancea has led to an increased… read more here.
Keywords: unraveling molecular; stem formation; atractylodes lancea; flat stem ... See more keywords
Unraveling the Molecular Landscape of kAE1: A Narrative Review.
Sign Up to like & getrecommendations! Published in 2024 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2023-0482
Abstract: Kidney anion exchanger 1 (kAE1) is an isoform of the AE1 protein encoded by the SLC4A1 gene. It is a basolateral membrane protein expressed by α-intercalated cells in the connecting tubules and collecting duct of… read more here.
Keywords: unraveling molecular; review; kae1 narrative; landscape kae1 ... See more keywords