Unravelling the instability of mutational signatures extraction via archetypal analysis
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DOI: 10.3389/fgene.2022.1049501
Abstract: The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts. The newest version (v3.3) of the signature database available in the… read more here.
Keywords: instability mutational; unravelling instability; archetypal analysis; mutational signatures ... See more keywords