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   Articles with "unrelated donor" as a keyword



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Younger haploidentical donor versus older matched unrelated donor for patients with AML/MDS

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recommendations! Published in 2023 at "American Journal of Hematology"

DOI: 10.1002/ajh.26870

Abstract: Optimal donor selection is fundamental to successful allogeneic hematopoietic cell transplantation (HCT), and donor age influences survival after both matched unrelated donor (MUD) and haploidentical donor HCT. Though recent studies have shown similar outcomes between… read more here.

Keywords: matched unrelated; haploidentical donor; unrelated donor; hct ... See more keywords
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Considerations for haploidentical versus unrelated donor transplants

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recommendations! Published in 2019 at "Bone Marrow Transplantation"

DOI: 10.1038/s41409-019-0613-2

Abstract: Haploidentical transplantation is increasingly performed worldwide due to novel methods to control alloreactivity between the donor and recipient. This major advancement has increased donor availability to almost all patients in need. Outcomes with haploidenitcal donors… read more here.

Keywords: unrelated donor; donor transplants; haploidentical versus; considerations haploidentical ... See more keywords
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Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades

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recommendations! Published in 2023 at "Stem Cells Translational Medicine"

DOI: 10.1093/stcltm/szac079

Abstract: Abstract Four decades ago, Broxmeyer et al. demonstrated that umbilical cord blood (CB) contained hematopoietic stem cells (HSC) and hypothesized that CB could be used as a source of donor HSC for rescue of myeloablated… read more here.

Keywords: cord; time; unrelated donor; cord blood ... See more keywords
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Comparable survival outcome between transplantation from haploidentical donor and matched related donor or unrelated donor for severe aplastic anemia patients aged 40 years and older: A retrospective multicenter cohort study

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recommendations! Published in 2020 at "Clinical Transplantation"

DOI: 10.1111/ctr.13810

Abstract: This retrospective multicenter cohort study aimed to compare the outcome of haploidentical hematopoietic stem cell transplantation (HID‐HSCT) with matched sibling donor (MSD) and unrelated donor (URD) transplantation in severe aplastic anemia (SAA) patients 40 years… read more here.

Keywords: donor; transplantation; retrospective multicenter; unrelated donor ... See more keywords
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Abatacept Is Effective for Gvhd Prophylaxis after Unrelated Donor Stem Cell Transplantation (URD SCT) for Severe Sickle Cell Disease (SCD)

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-126405

Abstract: Background In 2016, results from the first URD SCT for SCD (the SCURT Trial) revealed a 2-year overall survival (OS) and event-free survival (EFS) of 79% (95% CI 59-90) and 69% (95% CI, 48-82) respectively… read more here.

Keywords: disease; scd; urd sct; unrelated donor ... See more keywords
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Is a matched unrelated donor search needed for all allogeneic transplant candidates?

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recommendations! Published in 2018 at "Blood advances"

DOI: 10.1182/bloodadvances.2018021899

Abstract: Donor availability for allogeneic transplantation remains an important factor in determining outcomes of a successful transplant. We examined outcomes of 242 patients treated over 3 years who had a matched unrelated donor (MUD) search at… read more here.

Keywords: matched unrelated; search; transplant; unrelated donor ... See more keywords
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Improved GRFS after posttransplant cyclophosphamide-based vs ATG-based HLA-mismatched unrelated donor transplant

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recommendations! Published in 2022 at "Blood Advances"

DOI: 10.1182/bloodadvances.2022007596

Abstract: Abstract A common method to prevent graft-versus-host disease after allogeneic hematopoietic cell transplantation (HCT) from an HLA-mismatched unrelated donor (MMUD) is tacrolimus, methotrexate, and antithymocyte globulin (ATG). The use of posttransplant cyclophosphamide (PTCy) showed promise… read more here.

Keywords: mismatched unrelated; atg; unrelated donor; hla mismatched ... See more keywords
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Inaccuracies in assignment of patient race and ethnicity: implications for unrelated donor searches and health care delivery

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recommendations! Published in 2022 at "Blood Advances"

DOI: 10.1182/bloodadvances.2022008526

Abstract: Accurate patient ancestry determination is critical in the evaluation of candidates for allogeneic bone marrow transplantation (BMT) without suitable related donors, given that patients with non-European ancestry are much less likely to have an 8… read more here.

Keywords: assignment patient; ancestry; unrelated donor; inaccuracies assignment ... See more keywords
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Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation

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recommendations! Published in 2023 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.22.01229

Abstract: PURPOSE Immunopeptidome divergence between mismatched HLA-DP is a determinant of T-cell alloreactivity and clinical tolerability after fully HLA-A, -B, -C, -DRB1, -DQB1 matched unrelated donor hematopoietic cell transplantation (UD-HCT). Here, we tested this concept in… read more here.

Keywords: hla; pbm; unrelated donor; hla mismatched ... See more keywords
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Is unrelated donor or haploidentical hematopoietic transplantation preferred for patients with acute myeloid leukemia in remission?

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recommendations! Published in 2020 at "Haematologica"

DOI: 10.3324/haematol.2019.239624

Abstract: In this issue, Perales et al. 1 address a controversy in hematopoietic stem cell transplantation: should an HLA-matched unrelated donor or haploidentical transplant be performed for patients who lack a matched sibling? The preferred donor… read more here.

Keywords: matched unrelated; haplohsct; donor; relapse ... See more keywords
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Reduction of Relapse after Unrelated Donor Stem Cell Transplantation by KIR-Based Graft Selection

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recommendations! Published in 2017 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2017.00041

Abstract: Besides donor T cells, natural killer (NK) cells are considered to have a major role in preventing relapse after allogeneic hematopoietic stem cell transplantation (HSCT). After T-cell-depleted haploidentical HSCT, a strong NK alloreactivity has been… read more here.

Keywords: kir; cell transplantation; relapse; stem cell ... See more keywords