Shogaol but not gingerol has a neuroprotective effect on hemorrhagic brain injury: Contribution of the &agr;, &bgr;‐unsaturated carbonyl to heme oxygenase‐1 expression
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.029
Abstract: Abstract We investigated the effects of shogaol, which has an &agr;, &bgr;‐unsaturated carbonyl group, and gingerol, which does not, on primary‐cultured microglia to understand how the &agr;, &bgr;‐unsaturated carbonyl interacts with Kelch‐like ECH‐associated protein (Keap)1.… read more here.
Keywords: agr bgr; heme oxygenase; bgr unsaturated; unsaturated carbonyl ... See more keywords
DNA Compatible Intermolecular Wittig Olefination for the Construction of α, β-Unsaturated Carbonyl Compounds.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01215
Abstract: A robust DNA-compatible Wittig reaction mediated by PPh2CH3 has been validated for DNA-conjugated α-chloroacetamides with aldehydes and, alternatively, DNA-conjugated aldehydes with α-halo acetamides or ketones. Further, 2-aminopyridines were acylated with α-chloroacetyl chloride and then reacted… read more here.
Keywords: dna compatible; carbonyl compounds; compatible intermolecular; unsaturated carbonyl ... See more keywords
Manganese(I)-Catalyzed Asymmetric Hydrophosphination of α,β-Unsaturated Carbonyl Derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c04256
Abstract: Here we report catalytic asymmetric hydrophosphination of α,β-unsaturated carbonyl derivatives using a chiral Mn(I) complex as a catalyst. Through H–P bond activation, various phosphine-containing chiral products can be accessed via hydrophosphination of various ketone-, ester-,… read more here.
Keywords: manganese catalyzed; unsaturated carbonyl; asymmetric hydrophosphination; hydrophosphination ... See more keywords
A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04531
Abstract: An efficient method for the preparation of β-amino-α,β-unsaturated carbonyl compounds is demonstrated. Bench-stable sodium 3-oxo-enolates were prepared from carbonyl compounds, and reacted with amines in the presence of an acid and a desiccant. DFT studies… read more here.
Keywords: preparation amino; method preparation; carbonyl compounds; unsaturated carbonyl ... See more keywords
Selective hydrogenation of α,β-unsaturated carbonyl compounds on silica-supported copper nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc08457b
Abstract: Silica-supported copper nanoparticles prepared via surface organometallic chemistry are highly efficient for the selective hydrogenation of various α,β-unsaturated carbonyl compounds yielding the corresponding saturated esters, ketones, and aldehydes in the absence of additives. High conversions… read more here.
Keywords: supported copper; hydrogenation; selective hydrogenation; unsaturated carbonyl ... See more keywords
Catalyst-free chemoselective α-sulfenylation/β-thiolation for α,β-unsaturated carbonyl compounds
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra05708k
Abstract: This catalyst-free method provides a useful and efficient tool for the highly chemoselective preparation of α-thiolation or β-sulfenylation products of α,β-unsaturated carbonyl compounds. read more here.
Keywords: unsaturated carbonyl; carbonyl compounds; free chemoselective; sulfenylation ... See more keywords
Phosphine-catalysed (4+1) annulations of β'-acetoxy allenoate with β,γ-unsaturated carbonyl compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc00368b
Abstract: While β,γ-unsaturated carbonyl compounds have been widely used as γC- or αC-nucleophiles, their potential αC,αC-bisnucleophilic reactivity is still underdeveloped. Herein, a phosphine-catalysed (4+1) annulation of β'-acetoxy allenoate and a β,γ-unsaturated carbonyl compound is reported, wherein… read more here.
Keywords: allenoate unsaturated; acetoxy allenoate; carbonyl compounds; phosphine catalysed ... See more keywords
Stereoselective synthesis of (Z)-1,3-bis(α,β-unsaturated carbonyl)-isoindolines from aldehydes and phenacyl azides under metal free conditions.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc02884g
Abstract: Here in the present manuscript, we report our observation of an unprecedented stereoselective synthesis of 2H-isoindolin-1,3-ylidenes from 2-(formylphenyl)acrylates and phenacylazide in the presence of piperidine. Unlike in our previous findings, in which we accessed 3-keto-isoquinolines… read more here.
Keywords: carbonyl isoindolines; bis unsaturated; stereoselective synthesis; synthesis bis ... See more keywords
Studies of adsorption of α,β-unsaturated carbonyl compounds on heterogeneous Au/CeO2, Au/TiO2 and Au/SiO2 catalysts during reduction by hydrogen
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra09434c
Abstract: Our research focuses on phenomena accompanying adsorption of mesityl oxide (4-methylpent-3-en-2-one) on the surface of heterogeneous supported gold catalysts: Au/CeO2, Au/TiO2 and Au/SiO2. We have studied reduction in the gas phase of (volatile) α,β-unsaturated carbonyl… read more here.
Keywords: 320 320; unsaturated carbonyl; tio2 sio2; ceo2 tio2 ... See more keywords
Fe(OTf)3-catalysed Friedel–Crafts reaction of benzenoid arenes with α,β-unsaturated carbonyl compounds: easy access to 1,1-diarylalkanes
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DOI: 10.1098/rsos.170748
Abstract: A simple and efficient method for the synthesis of 1,1-diarylalkanes via the Friedel–Crafts-type alkylation reaction of electron-rich arenes with cinnamic acid ester derivatives or chalcones is reported. Iron triflate has been found to be the… read more here.
Keywords: otf catalysed; carbonyl compounds; reaction; catalysed friedel ... See more keywords
Thermodynamics Evaluation of Selective Hydride Reduction for α,β-Unsaturated Carbonyl Compounds
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DOI: 10.3390/molecules28062862
Abstract: The selective reduction of α,β-unsaturated carbonyl compounds is one of the core reactions and also a difficult task for organic synthesis. We have been attempting to study the thermodynamic data of these compounds to create… read more here.
Keywords: unsaturated carbonyl; reduction unsaturated; thermodynamics; carbonyl compounds ... See more keywords