Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102299
Abstract: Humans are commonly exposed to α,β-unsaturated carbonyls as both environmental toxins (e.g. acrolein) and therapeutic drugs (e.g. dimethylfumarate, DMFU, a front-line drug for the treatment of multiple sclerosis and psoriasis). These compounds undergo rapid Michael… read more here.
Keywords: chemistry; cellular targets; unsaturated carbonyls; synthesis cellular ... See more keywords
Synthesis and cytotoxic effect of pregnenolone derivatives with one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.01.004
Abstract: Graphical abstract Figure. No caption available. HighlightsSynthesis of four series of pregnenolone derivatives.Comparison study between the cytotoxicity of steroids with an ester group at C‐21 or C‐3 (in four cell lines).Determination of the cytotoxic effect… read more here.
Keywords: one two; pregnenolone derivatives; unsaturated carbonyls; effect ... See more keywords
Reactions of α,β-Unsaturated Carbonyls with Free Chlorine, Free Bromine, and Combined Chlorine.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental science & technology"
DOI: 10.1021/acs.est.0c07660
Abstract: Chemical disinfectants employed in water and wastewater treatment can produce a variety of transformation products, including carbonyl compounds (e.g., saturated and unsaturated aldehydes and ketones). Experiments conducted under conditions relevant to chlorination at drinking water… read more here.
Keywords: free chlorine; unsaturated carbonyls; chlorine free; combined chlorine ... See more keywords
Occurrence and Synthesis Pathways of (Suspected) Genotoxic α,β-Unsaturated Carbonyls in Chocolate and Other Commercial Sweet Snacks.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c01043
Abstract: α,β-Unsaturated carbonyls are highly reactive and described as structural alerts for genotoxicity. Ten of them (either commercially available or synthesized here by combinatorial chemistry) were first investigated throughout the chocolate-making process by solvent-assisted flavor evaporation… read more here.
Keywords: unsaturated carbonyls; chemistry; chocolate; commercial sweet ... See more keywords