Copper-Promoted 6- endo-trig Cyclization of β,γ-Unsaturated Hydrazones for the Synthesis of 1,6-Dihydropyridazines.
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DOI: 10.1021/acs.orglett.8b01240
Abstract: A novel and efficient strategy for the synthesis of 1,6-dihydropyridazines via copper-promoted 6- endo-trig cyclization of readily available β,γ-unsaturated hydrazones have been developed. A series of 1,6-dihydropyridazines have been synthesized by this method with good… read more here.
Keywords: copper promoted; trig cyclization; promoted endo; endo trig ... See more keywords
Copper(I)-Catalyzed Oxyamination of β,γ-Unsaturated Hydrazones: Synthesis of Dihydropyrazoles.
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DOI: 10.1021/acs.orglett.9b02733
Abstract: An efficient aerobic copper(I)-catalyzed oxyamination of β,γ-unsaturated hydrazones has been developed. The methodology provides effective access to dihydropyrazole derivatives in a one-pot process utilizing dioxygen as a sustainable sacrificial oxidant. Mechanistic studies have been performed… read more here.
Keywords: oxyamination unsaturated; hydrazones synthesis; copper catalyzed; catalyzed oxyamination ... See more keywords
Brønsted acid-promoted hydroamination of unsaturated hydrazones: access to biologically important 5-arylpyrazolines
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DOI: 10.1039/d1ra03043d
Abstract: An efficient, chemo- and regioselective Brønsted acid-promoted hydroamination reaction of hydrazone-tethered olefins towards 5-arylpyrazolines was developed. read more here.
Keywords: unsaturated hydrazones; promoted hydroamination; hydroamination unsaturated; acid promoted ... See more keywords