Asymmetric Synthesis of α,β-Unsaturated δ-Lactones through Copper(I)-Catalyzed Direct Vinylogous Aldol Reaction.
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DOI: 10.1021/jacs.8b07929
Abstract: A simple methodology for the asymmetric synthesis of chiral α,β-unsaturated δ-lactones was achieved by copper(I)-catalyzed direct vinylogous aldol reaction (DVAR) of β,γ-unsaturated esters and various aldehydes, including aromatic aldehydes, heteroaromatic aldehydes, α,β-unsaturated aldehydes, and aliphatic… read more here.
Keywords: methodology; unsaturated lactones; copper; reaction ... See more keywords
Electrophilic reactivities of cyclic enones and α,β-unsaturated lactones†
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DOI: 10.1039/d0sc06628a
Abstract: The reactivities of cyclic enones and α,β-unsaturated lactones were characterized by following the kinetics of their reactions with colored carbon-centered reference nucleophiles in DMSO at 20 °C. The experimentally determined second-order rate constants k2 were… read more here.
Keywords: unsaturated lactones; cyclic enones; enones unsaturated; reactivity ... See more keywords