The unstructured linker of Mlh1 contains a motif required for endonuclease function which is mutated in cancers
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DOI: 10.1073/pnas.2212870119
Abstract: Significance DNA mismatch repair (MMR) prevents mutations caused by DNA-replication errors and suppresses multiple types of cancers. During MMR, the Mlh1-Pms1 complex is recruited to mispair-containing DNA and nicks the newly replicated DNA strand, targeting… read more here.
Keywords: linker mlh1; linker; unstructured linker; required endonuclease ... See more keywords