Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation.
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DOI: 10.1021/acs.jmedchem.3c00053
Abstract: GPR84 is a proinflammatory G protein-coupled receptor that mediates myeloid immune cell functions. Blocking GPR84 with antagonists is a promising approach for treating inflammatory and fibrotic diseases. Previously, a GPR84 antagonist 604c, with a symmetrical… read more here.
Keywords: gpr84 antagonists; lung inflammation; unsymmetrical phosphodiesters; blood ... See more keywords