Cluster Analysis of Untargeted Metabolomic Experiments.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8757-3_16
Abstract: Untargeted metabolite profiling based upon LC-MS methodology can be used to identify unique metabolic phenotypes associated with stress, disease or environmental exposure of cells using mathematical clustering. Here, we show how unsupervised data analysis is… read more here.
Keywords: statistical computing; metabolomic experiments; cluster analysis; analysis ... See more keywords
A Protocol to Compare Methods for Untargeted Metabolomics.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8769-6_1
Abstract: There are thousands of published methods for profiling metabolites with liquid chromatography/mass spectrometry (LC/MS). While many have been evaluated and optimized for a small number of select metabolites, very few have been assessed on the… read more here.
Keywords: protocol compare; methods untargeted; untargeted metabolomic; mass ... See more keywords
Comparative evaluation of comprehensive offline 2D-LC strategies coupled to MS for untargeted metabolomic studies of human urine
Sign Up to like & getrecommendations! Published in 2025 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-025-06195-2
Abstract: Out of the broad selection of analytical methods applied in metabolomic studies, liquid chromatography coupled to mass spectrometry (LC-MS) has the highest coverage potential. In that regard, the quality of the separation process is crucial… read more here.
Keywords: human urine; untargeted metabolomic; offline; metabolomic studies ... See more keywords
Active biomonitoring of stream ecosystems: untargeted metabolomic and proteomic responses and free radical scavenging activities in mussels
Sign Up to like & getrecommendations! Published in 2025 at "Ecotoxicology"
DOI: 10.1007/s10646-024-02846-9
Abstract: Many contaminants from scattered sources constantly endanger streams that flow through heavily inhabited areas, commercial districts, and industrial hubs. The responses of transplanted mussels in streams in active biomonitoring programs will reflect the dynamics of… read more here.
Keywords: proteomic responses; untargeted metabolomic; active biomonitoring; metabolomic proteomic ... See more keywords
Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.03.020
Abstract: BACKGROUND Although thousands of different chemicals have been identified in cigarette smoke, the characterization of their urinary metabolites still requires significant research. The aim of this work was to perform an untargeted metabolomic approach to… read more here.
Keywords: different smoking; untargeted metabolomic; smoking habits; metabolomic approach ... See more keywords
Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09908-5
Abstract: While predominant as a disease entity, knowledge voids exist regarding the pathogenesis of canine diabetes. To test the hypothesis that diabetic dogs have similar metabolomic perturbations to humans with type 1 diabetes (T1D), we analyzed… read more here.
Keywords: analysis; canine; canine diabetes; untargeted metabolomic ... See more keywords
Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-80492-1
Abstract: Diabetic nephropathy (DN) is one of the major causes of end-stage renal disease. This study aimed to explore the internal relationship between metabolic processes and autoimmune responses in patients with DN via untargeted metabolomics and… read more here.
Keywords: untargeted metabolomic; analysis; metabolomic proteomic; proteomic analysis ... See more keywords
Chemometrics assisted untargeted metabolomic analysis to explore metabolic alterations in chronic urticaria via LC/Q-TOF/MS/MS
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2129436
Abstract: Abstract Chronic urticaria (CU) is a common disease characterized by the development of recurrent itchy blisters and/or angioedema lasting longer than 6 weeks. The evidence-based diagnosis of CU is described in the most recent urticaria guideline.… read more here.
Keywords: assisted untargeted; chronic urticaria; analysis; metabolomic analysis ... See more keywords
Untargeted Metabolomic Investigation of Wheat Infected with Stinking Smut Tilletia caries.
Sign Up to like & getrecommendations! Published in 2021 at "Phytopathology"
DOI: 10.1094/phyto-09-20-0383-r
Abstract: Tilletia caries infection of wheat (Triticum aestivum) has become an increasing problem in organic wheat agriculture throughout the world. Little is known about how this pathogen alters host metabolism to ensure a successful infection. We… read more here.
Keywords: metabolomic investigation; untargeted metabolomic; wheat; tilletia caries ... See more keywords
Untargeted Metabolomic Analysis of Leaves and Roots of Jatropha curcas Genotypes with Contrasting Levels of Phorbol Esters.
Sign Up to like & getrecommendations! Published in 2024 at "Physiologia plantarum"
DOI: 10.1111/ppl.14274
Abstract: AIMS Phorbol esters (PE) are toxic diterpenoids accumulated in physic nut (Jatropha curcas L.) seed tissues. Their biosynthetic pathway remains unknown, and the participation of roots in this process may be possible. Thus, we set… read more here.
Keywords: leaves roots; phorbol esters; untargeted metabolomic; metabolomic analysis ... See more keywords
Targeted and untargeted metabolomic approach for GDM diagnosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.997436
Abstract: Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and is mainly connected with glucose metabolism. It is also known that fatty acid profile changes in erythrocyte membranes… read more here.
Keywords: gdm; fatty acids; oleic acid; targeted untargeted ... See more keywords