Cluster Analysis of Untargeted Metabolomic Experiments.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8757-3_16
Abstract: Untargeted metabolite profiling based upon LC-MS methodology can be used to identify unique metabolic phenotypes associated with stress, disease or environmental exposure of cells using mathematical clustering. Here, we show how unsupervised data analysis is… read more here.
Keywords: statistical computing; metabolomic experiments; cluster analysis; analysis ... See more keywords
A Protocol to Compare Methods for Untargeted Metabolomics.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8769-6_1
Abstract: There are thousands of published methods for profiling metabolites with liquid chromatography/mass spectrometry (LC/MS). While many have been evaluated and optimized for a small number of select metabolites, very few have been assessed on the… read more here.
Keywords: protocol compare; methods untargeted; untargeted metabolomic; mass ... See more keywords
Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.03.020
Abstract: BACKGROUND Although thousands of different chemicals have been identified in cigarette smoke, the characterization of their urinary metabolites still requires significant research. The aim of this work was to perform an untargeted metabolomic approach to… read more here.
Keywords: different smoking; untargeted metabolomic; smoking habits; metabolomic approach ... See more keywords
Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09908-5
Abstract: While predominant as a disease entity, knowledge voids exist regarding the pathogenesis of canine diabetes. To test the hypothesis that diabetic dogs have similar metabolomic perturbations to humans with type 1 diabetes (T1D), we analyzed… read more here.
Keywords: analysis; canine; canine diabetes; untargeted metabolomic ... See more keywords
Chemometrics assisted untargeted metabolomic analysis to explore metabolic alterations in chronic urticaria via LC/Q-TOF/MS/MS
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2129436
Abstract: Abstract Chronic urticaria (CU) is a common disease characterized by the development of recurrent itchy blisters and/or angioedema lasting longer than 6 weeks. The evidence-based diagnosis of CU is described in the most recent urticaria guideline.… read more here.
Keywords: assisted untargeted; chronic urticaria; analysis; metabolomic analysis ... See more keywords
Untargeted Metabolomic Investigation of Wheat Infected with Stinking Smut Tilletia caries.
Sign Up to like & getrecommendations! Published in 2021 at "Phytopathology"
DOI: 10.1094/phyto-09-20-0383-r
Abstract: Tilletia caries infection of wheat (Triticum aestivum) has become an increasing problem in organic wheat agriculture throughout the world. Little is known about how this pathogen alters host metabolism to ensure a successful infection. We… read more here.
Keywords: metabolomic investigation; untargeted metabolomic; wheat; tilletia caries ... See more keywords
Targeted and untargeted metabolomic approach for GDM diagnosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.997436
Abstract: Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and is mainly connected with glucose metabolism. It is also known that fatty acid profile changes in erythrocyte membranes… read more here.
Keywords: gdm; fatty acids; oleic acid; targeted untargeted ... See more keywords
Untargeted Metabolomic Approach of Curcuma longa to Neurodegenerative Phytocarrier System Based on Silver Nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11112261
Abstract: Curcuma is one of the most famous medicinal and tropical aromatic plants. Its health benefits have been appreciated and exploited in traditional Asian medicine since ancient times. Various studies have investigated its complex chemical composition… read more here.
Keywords: curcuma; phytocarrier system; phytocarrier; untargeted metabolomic ... See more keywords
Untargeted Metabolomic Characterization of Ovarian Tumors
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DOI: 10.3390/cancers12123642
Abstract: Simple Summary This study utilized untargeted metabolomic techniques to detect urine and plasma metabolites. Using support vector machine algorithm, three models for ovarian tumors diagnosis, benign-malignant distinguishing, early diagnosis and borderline-malignant distinguishing were developed. These… read more here.
Keywords: ovarian tumors; diagnosis; untargeted metabolomic; urine plasma ... See more keywords
Untargeted Metabolomic Assay of Prefrail Older Adults after Nutritional Intervention
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12050378
Abstract: Frailty is a geriatric syndrome causing a reduction in the body’s functional reserves. Proper nutrition may be helpful in delaying transitioning older adults from pre-frail to frailty syndrome. The present study evaluates the nutritional status… read more here.
Keywords: nutritional intervention; metabolomic assay; frail patients; pre frail ... See more keywords
Human Archaeological Dentin as Source of Polar and Less Polar Metabolites for Untargeted Metabolomic Research: The Case of Yersinia pestis
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13050588
Abstract: Metabolomic approaches, such as in clinical applications of living individuals, have shown potential use for solving questions regarding the past when applied to archaeological material. Here, we study for the first time the potential of… read more here.
Keywords: less polar; polar less; untargeted metabolomic; archaeological dentin ... See more keywords