Untargeted metabolomics reveals hepatic metabolic disorder in the BTBR mouse model of autism and the significant role of liver in autism.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3811
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and the etiology is unknown. Metabolic dysfunction is present in patients with ASD. In the current study, untargeted metabolomics was employed to screen the differential metabolites in… read more here.
Keywords: untargeted metabolomics; mouse model; liver; autism ... See more keywords
Determination of the Time since Deposition of Blood-traces in a Forensic Context: Application of Untargeted LC-HR-MS/MS Metabolomics Profiling.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3480
Abstract: Being able to attest when a bloodstain was deposited at a crime scene can be invaluable to a prosecution process, and methods to provide that information have long been desired. Determining the Time since Deposition… read more here.
Keywords: untargeted metabolomics; time; since deposition; tsd ... See more keywords
Untargeted metabolomics of strawberry (Fragaria x ananassa 'Camarosa') fruit from plants grown under osmotic stress conditions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.9986
Abstract: BACKGROUND In order to cope with adverse environmental conditions, plants activate defense mechanisms leading to the accumulation and/or depletion of general and specialized metabolites. In this study, a multiplatform untargeted metabolomics strategy was employed to… read more here.
Keywords: stress conditions; fruit; grown osmotic; osmotic stress ... See more keywords
A Protocol to Compare Methods for Untargeted Metabolomics.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8769-6_1
Abstract: There are thousands of published methods for profiling metabolites with liquid chromatography/mass spectrometry (LC/MS). While many have been evaluated and optimized for a small number of select metabolites, very few have been assessed on the… read more here.
Keywords: protocol compare; methods untargeted; untargeted metabolomic; mass ... See more keywords
Data Processing for GC-MS- and LC-MS-Based Untargeted Metabolomics.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9236-2_18
Abstract: Gas chromatography and liquid chromatography coupled to mass spectrometry are used extensively in untargeted metabolomics, which involves the profiling of small metabolites in biological samples. The complex raw dataset produced from untargeted metabolomics requires proper… read more here.
Keywords: processing based; data processing; biology; based untargeted ... See more keywords
Investigation of the relationships between knee osteoarthritis and obesity via untargeted metabolomics analysis
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Rheumatology"
DOI: 10.1007/s10067-019-04428-1
Abstract: ObjectiveOsteoarthritis (OA), the most encountered arthritis form, result from degeneration of articular cartilage. Obesity is accepted as a significant risk factor for knee OA (KOA). In this study, it is aimed to determine the variation of… read more here.
Keywords: via untargeted; analysis; control; group ... See more keywords
Untargeted metabolomics based on ultra-high-performance liquid chromatography-high-resolution mass spectrometry merged with chemometrics: A new predictable tool for an early detection of mycotoxins.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2016.11.132
Abstract: In order to explore the early detection of mycotoxins in wheat three standardized approaches (Fusarium disease severity, PCR assays for Fusarium spp. identification and mycotoxin quantification) and a novel untargeted metabolomics strategy were jointly assessed.… read more here.
Keywords: early detection; based ultra; detection mycotoxins; metabolomics based ... See more keywords
Integrating untargeted metabolomics and targeted analysis for not from concentrate and from concentrate orange juices discrimination and authentication.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.127130
Abstract: Untargeted metabolomics was used to investigate the differences between orange juices from concentrate or not. Although no distinctive separation could be observed from principal component analysis for all samples, student's t-test, fold change, orthogonal projection… read more here.
Keywords: analysis; time; orange juices; concentrate ... See more keywords
Edible nuts deliver polyphenols and their transformation products to the large intestine: An in vitro fermentation model combining targeted/untargeted metabolomics.
Sign Up to like & getrecommendations! Published in 2019 at "Food research international"
DOI: 10.1016/j.foodres.2018.09.012
Abstract: The fate of polyphenols from edible tree nuts was investigated using a simulated in vitro intestinal fermentation system. The digested food matrix was fermented for 48 h and the changes in the phenolic profiles were evaluated… read more here.
Keywords: fermentation; nuts deliver; vitro fermentation; phenolic metabolites ... See more keywords
Neuroprotective potential of Ayahuasca and untargeted metabolomics analyses: Applicability to Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112743
Abstract: ETHNOPHARMACOLOGY RELEVANCE Ayahuasca is a tea produced through decoction of Amazonian plants. It has been used for centuries by indigenous people of South America. The beverage is considered to be an ethnomedicine, and it is… read more here.
Keywords: ayahuasca; parkinson disease; potential ayahuasca; neuroprotective potential ... See more keywords
Untargeted metabolomics to investigate the phenolic composition of Chardonnay wines from different origins
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Food Composition and Analysis"
DOI: 10.1016/j.jfca.2018.05.010
Abstract: Abstract Chardonnay is a grape variety widely used to produce different white wine styles. In this work, a metabolomic approach based on ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-ESI/QTOF-MS) has been applied… read more here.
Keywords: chardonnay wines; wines different; chardonnay; phenolic composition ... See more keywords