Untargeted 2D NMR Metabolomics of [13C-methyl]Methionine-Labeled Tumor Models Reveals the Non-DNA Methylome and Provides Clues to Methyl Metabolism Shift during Tumor Progression.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00778
Abstract: For more than a decade, DNA and histone methylations have been the focus of extensive work, although their relationship with methyl group metabolism was overlooked. Recently, it has emerged that epigenetic methylations are influenced by… read more here.
Keywords: tumor; metabolism; nmr metabolomics; methionine ... See more keywords
AlpsNMR: an R package for signal processing of fully untargeted NMR-based metabolomics
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DOI: 10.1093/bioinformatics/btaa022
Abstract: RESULTS NMR-based metabolomics is widely used to obtain metabolic fingerprints of biological systems. While targeted workflows require previous knowledge of metabolites, prior to statistical analysis, untargeted approaches remain a challenge. Computational tools dealing with fully… read more here.
Keywords: package; processing; fully untargeted; based metabolomics ... See more keywords
Untargeted NMR Metabolomics Reveals Alternative Biomarkers and Pathways in Alkaptonuria
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DOI: 10.3390/ijms232415805
Abstract: Alkaptonuria (AKU) is an ultra-rare metabolic disease caused by the accumulation of homogentisic acid (HGA), an intermediate product of phenylalanine and tyrosine degradation. AKU patients carry variants within the gene coding for homogentisate-1,2-dioxygenase (HGD), which… read more here.
Keywords: biomarkers pathways; untargeted nmr; alternative biomarkers; reveals alternative ... See more keywords