3′ Untranslated Region Structural Elements in CYP24A1 Are Associated With Infantile Hypercalcemia Type 1
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4769
Abstract: Loss‐of‐function mutations in the CYP24A1 protein‐coding region causing reduced 25 hydroxyvitamin D (25OHD) and 1,25 dihydroxyvitamin D (1,25(OH)2D) catabolism have been observed in some cases of infantile hypercalcemia type 1 (HCINF1), which can manifest as… read more here.
Keywords: untranslated region; hypercalcemia; infantile hypercalcemia; structural elements ... See more keywords
One functional variant in the 3′‐untranslated region of TLR4 is associated with the elevated risk of ventilator‐associated pneumonia in the patients with chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28526
Abstract: The aim of this study was to identify the association polymorphism (rs11536889) in the 3′‐untranslated region (3′‐UTR) of Toll‐like receptors 4 (TLR4) and the risk for ventilator‐associated pneumonia (VAP). miRNA database online and luciferase assays… read more here.
Keywords: risk; ventilator associated; associated pneumonia; risk ventilator ... See more keywords
Regulation of ATF1 and ATF2 transcripts by sequences in their 3′ untranslated region in cleavage‐stage cattle embryos
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22785
Abstract: The sequence of a 3′ untranslated region (3′UTR) of mRNA governs the timing of its polyadenylation and translation in mammalian oocytes and early embryos. The objective of this study was to assess the influence of… read more here.
Keywords: atf1 atf2; gfp; translation; atf2 transcripts ... See more keywords
Characterization of a putative ribosome binding site at the 5' untranslated region of bovine heat shock protein 90.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05768-x
Abstract: Untranslated regions (UTRs) of the transcripts play significant roles in translation regulation and continue to raise many intriguing questions in our understanding of cellular stress physiology. Internal ribosome entry site (IRES) mediated alternative translation initiations… read more here.
Keywords: bovine; site; bovine heat; untranslated region ... See more keywords
P191 A first evaluation of the HLA-A gene 3′ untranslated region diversity in Brazil and its relationship with coding haplotypes
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.251
Abstract: Aim Here we propose a NGS strategy to evaluate the HLA-A coding and 3′UTR variability and get reliable haplotypes. Then, we present the data obtained in very admixed population (Brazil). Methods The HLA-Agene segment was… read more here.
Keywords: segment; untranslated region; variability; hla ... See more keywords
Arabidopsis thaliana cold-regulated 47 gene 5'-untranslated region enables stable high-level expression of transgenes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2017.08.007
Abstract: Transgene expression is regulated through several steps, this study focuses on the mRNA translation step. The expression level of transgenes can be increased by 5'-untranslated region (5'UTR) sequences in certain genes which act as translational… read more here.
Keywords: cold regulated; level; expression; regulated gene ... See more keywords
Evaluation of the Function of a Rare Variant in the 3'-Untranslated Region of the β-Globin Gene
Sign Up to like & getrecommendations! Published in 2022 at "Hemoglobin"
DOI: 10.1080/03630269.2023.2167660
Abstract: Abstract β-Thalassemia (β-thal) is an inherited genetic disease that occurs because of the absence or reduction of β-globin chain synthesis. Genetic changes occur in different regions of the β-globin gene, but these mutations are less… read more here.
Keywords: globin gene; gene; rare variant; untranslated region ... See more keywords
Comparison of Rhinovirus A–, B–, and C–Associated Respiratory Tract Illness Severity Based on the 5′-Untranslated Region Among Children Younger Than 5 Years
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac387
Abstract: Abstract Background Rhinoviruses (RVs) are among the most frequently detected viruses from hospitalized children with severe acute respiratory infections, being classified into RV-A, RV-B, and RV-C (4 clades: C, GAC1, GAC2, and A2). This study… read more here.
Keywords: tract illness; illness severity; respiratory tract; untranslated region ... See more keywords
c.-61G>A in OVOL2 is a Pathogenic 5′ Untranslated Region Variant Causing Posterior Polymorphous Corneal Dystrophy 1
Sign Up to like & getrecommendations! Published in 2021 at "Cornea"
DOI: 10.1097/ico.0000000000002843
Abstract: Purpose: The purpose of this study was to investigate the clinical and genetic features of a man and his daughter with posterior polymorphous corneal dystrophy (PPCD), referred to our clinic for Descemet membrane endothelial keratoplasty.… read more here.
Keywords: posterior polymorphous; histology; polymorphous corneal; untranslated region ... See more keywords
The selenoprotein P 3’ untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1101/2020.11.23.394817
Abstract: Selenoproteins contain the 21st amino acid, selenocysteine (Sec), which is incorporated at select UGA codons when a specialized hairpin sequence, the Sec insertion sequence (SECIS) element, is present in the 3’ UTR. Aside from the… read more here.
Keywords: binding protein; rna binding; untranslated region; selenoprotein ... See more keywords
A Polyuridine Insertion in the 3′ Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01214-19
Abstract: Classical swine fever (CSF), a highly contagious viral disease of pigs, is still endemic in some countries of Asia and Central and South America. Considering that the 3′ untranslated region (3′ UTR) plays an important… read more here.
Keywords: untranslated region; classical swine; virus; swine fever ... See more keywords