Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
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DOI: 10.1158/1535-7163.mct-17-0018
Abstract: Checkpoint-mediated dependency of tumor cells can be deployed to selectively kill them without substantial toxicity to normal cells. Specifically, loss of CHK1, a serine threonine kinase involved in the surveillance of the G2–M checkpoint in… read more here.
Keywords: dealkylation; chk1; synthesis profiling; unusual trifluoromethylpyrazole ... See more keywords