Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-017-1738-z
Abstract: There is substantial evidence implicating the urokinase system in tissue remodeling during neo-vascularization, inflammation, tumor invasion, and metastasis. Regulated degradation of the extracellular matrix at the leading edge of migrating cells, mediated by uPA and… read more here.
Keywords: pai; skin; upa upar; expression ... See more keywords
uPA/uPAR signaling in rheumatoid arthritis: Shedding light on its mechanism of action
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.05.016
Abstract: Graphical abstract Figure. No caption available. &NA; Rheumatoid arthritis (RA) is a systemic and chronic autoimmune inflammatory disorder affecting multiple joints. Various cytokines, chemokines and growth factors synergistically modulate the joint physiology leading to bone… read more here.
Keywords: plasminogen activator; upa upar; rheumatoid arthritis;
Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα
Sign Up to like & getrecommendations! Published in 2018 at "Integrative Cancer Therapies"
DOI: 10.1177/1534735417696702
Abstract: Gastric cancer (GC) is a malignancy with few effective treatment options after metastasis occurs. Quercetin (Qu) intake has been associated with reduced incidence and slow development of GC, probably due to its anti-proliferative and apoptotic… read more here.
Keywords: pkc erk1; erk1 ampk; upa upar; expression ... See more keywords
Prognostic significance of the urokinase plasminogen activator system in tissue and serum of dogs with appendicular osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0273811
Abstract: Urokinase plasminogen activator (uPA) and its receptor uPAR promote cancer invasion and metastasis and are emerging therapeutic targets in both human and canine malignancies. While their clinical significance is well-characterized in multiple human tumor types,… read more here.
Keywords: prognostic significance; canine; serum; upa upar ... See more keywords
Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.818616
Abstract: Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum protease, active on most… read more here.
Keywords: view; function urokinase; upa upar; cellular function ... See more keywords
The uPA/uPAR system in astrocytic wound healing
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.338991
Abstract: The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the… read more here.
Keywords: system; cell; neuronal cadherin; upa upar ... See more keywords