Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance
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DOI: 10.1002/cmdc.201700424
Abstract: The place of prodrugs in the current antitubercular therapeutic arsenal is preponderant, since two of the four first‐line antitubercular agents, isoniazid (INH) and pyrazinamide (PZA), need to be activated by Mycobacterium tuberculosis before exerting their… read more here.
Keywords: molecular perspective; update antitubercular; resistance; activation ... See more keywords