An update on the development of concepts, diagnostic criteria, and challenging issues for neuroendocrine neoplasms across different digestive organs
Sign Up to like & getrecommendations! Published in 2022 at "Virchows Archiv"
DOI: 10.1007/s00428-022-03306-7
Abstract: Digestive neuroendocrine neoplasms (NENs) are a group of heterogeneous neoplasms found throughout the digestive tract, with different behaviour and genetic background. In the last few years, nomenclature and WHO/UICC classifications of digestive NENs have changed,… read more here.
Keywords: concepts diagnostic; diagnostic criteria; neuroendocrine neoplasms; criteria challenging ... See more keywords
Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01290
Abstract: The proprotein convertase subtilisin/kexin-type 9 (PCSK9) binds to low-density lipoprotein receptors (LDLR), thereby trafficking them to lysosomes upon endocytosis and enhancing intracellular degradation to prevent their recycling. As a result, the levels of circulating LDL… read more here.
Keywords: pcsk9 inhibitors; inhibitors hypercholesterolemia; development pcsk9; pcsk9 ... See more keywords
An update on the development of novel antifungal agents for eumycetoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1165273
Abstract: Eumycetoma, a chronic subcutaneous mycosis, responds poorly to the available antifungal treatments and patients often require extensive surgical resection or amputation of the affected limb. More effective treatments are needed for eumycetoma. This article will… read more here.
Keywords: development novel; novel antifungal; update development; antifungal agents ... See more keywords
An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors
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DOI: 10.3390/molecules25215182
Abstract: Malaria control relies heavily on the small number of existing antimalarial drugs. However, recurring antimalarial drug resistance necessitates the continual generation of new antimalarial drugs with novel modes of action. In order to shift the… read more here.
Keywords: small molecule; development; update development; plasmodial kinase ... See more keywords