Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.
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DOI: 10.1021/acs.jmedchem.9b00188
Abstract: Important steps in embryonic development are governed by the Hedgehog (Hh) signaling pathway, an evolutionary conserved signal transduction cascade. However, Hh activity not only is crucial during embryo formation but also is involved in adult… read more here.
Keywords: update pharmacological; hedgehog update; inhibiting hedgehog; targeting strategies ... See more keywords
Update on the Pharmacological Treatment of Primary Biliary Cholangitis
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DOI: 10.3390/biomedicines10082033
Abstract: Ursodeoxycholic acid (UDCA) is the first-line therapy used for the treatment of PBC. In recent years, new pharmacological agents have been proposed for PBC therapy to cure UDCA-non-responders. Obeticholic acid (OCA) is registered in many… read more here.
Keywords: update pharmacological; pharmacological treatment; primary biliary; biliary cholangitis ... See more keywords