Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins
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DOI: 10.1242/jcs.198176
Abstract: ABSTRACT Nonsense-mutation-containing messenger ribonucleoprotein particles (mRNPs) transit through cytoplasmic foci called P-bodies before undergoing nonsense-mediated mRNA decay (NMD), a cytoplasmic mRNA surveillance mechanism. This study shows that the cytoskeleton modulates transport of nonsense-mutation-containing mRNPs to… read more here.
Keywords: cytoplasmic foci; upf proteins; termination codon; premature termination ... See more keywords