Synergistic Binding of ATP and Nucleic Acids Necessitates UPF1's ATPase Functional Cycle.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00247
Abstract: UPF1 is a core protein in the nonsense mRNA degradation (NMD) surveillance pathway that degrades aberrant mRNA. UPF1 has both ATPase and RNA helicase activities, but it exhibits mutually exclusive binding of ATP and RNA.… read more here.
Keywords: state; upf1 atpase; atp rna; atp ... See more keywords
Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants
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DOI: 10.7554/elife.57834
Abstract: Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated by the nonsense-mediated mRNA decay… read more here.
Keywords: atpase; termination codons; upf1 atpase; atpase mutants ... See more keywords