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UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

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0 Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.108925

Abstract: SUMMARY Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G4C2) hexanucleotide repeat expansion (HRE), including aspects of RNA regulation such as nonsense-mediated decay (NMD). Here, we investigate the role that… read more here.

Keywords: hre; mediated decay; neurotoxicity; upf1 reduces ... See more keywords