Comparison of Survival Outcomes Among Human Papillomavirus–Negative cT1-2 N1-2b Patients With Oropharyngeal Squamous Cell Cancer Treated With Upfront Surgery vs Definitive Chemoradiation Therapy: An Observational Study
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.5769
Abstract: Importance Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) has shown resistance to conventional concurrent chemoradiation (CRT) therapy and carries a relatively poor prognosis in comparison with HPV-positive disease, with decreased locoregional control and overall… read more here.
Keywords: surgery; observational study; ct1; therapy ... See more keywords
Long‐Term Outcomes of Neoadjuvant Therapy Versus Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma
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DOI: 10.1002/cam4.70363
Abstract: This study aimed to compare the long‐term effects of neoadjuvant therapy and upfront surgery on overall survival (OS) and progression‐free survival (PFS) in patients with resectable pancreatic ductal adenocarcinoma (PDAC). read more here.
Keywords: ductal adenocarcinoma; long term; neoadjuvant therapy; upfront surgery ... See more keywords
Axillary lymph node dissection in node-positive breast cancer: are ten nodes adequate and when is enough, enough?
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05500-9
Abstract: Purpose National guidelines define adequate axillary lymph node dissections as those yielding ≥ 10 lymph nodes (LNs). We aimed to identify the optimal LN yield among node-positive patients. Methods Using the National Cancer Data Base (2010–2015), we… read more here.
Keywords: lymph; breast cancer; node positive; upfront surgery ... See more keywords
Analysis of Carcinoma of the Esophagus Patients Between Upfront Surgery vs. Neoadjuvant Therapy Followed by Surgery
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Surgery"
DOI: 10.1007/s12262-020-02156-4
Abstract: In the management of carcinoma of the esophagus, neoadjuvant chemoradiation has shown to improve survival in many Western studies. It has still not become the standard of care in many centers due to perioperative morbidity/mortality… read more here.
Keywords: carcinoma esophagus; surgery; neoadjuvant therapy; upfront surgery ... See more keywords
Performance of different CT enhancement quantification methods as predictors of pancreatic cancer recurrence after upfront surgery
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DOI: 10.1038/s41598-024-70441-3
Abstract: The prognosis of pancreatic cancer (PDAC) after tumor resection remains poor, mostly due to a high but variable risk of recurrence. A promising tool for improved prognostication is the quantification of CT tumor enhancement. For… read more here.
Keywords: quantification; upfront surgery; tumor; pancreatic cancer ... See more keywords
Neoadjuvant therapy offers longer survival than upfront surgery for poorly differentiated and higher stage pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Acta Oncologica"
DOI: 10.1080/0284186x.2017.1415458
Abstract: Abstract Background: Neoadjuvant therapy for pancreatic cancer remains controversial. Our aim was to assess differences in survival, disease recurrence and histopathological tumor characteristics between patients treated with neoadjuvant therapy followed by subsequent surgery and patients… read more here.
Keywords: patients treated; neoadjuvant therapy; therapy; treated neoadjuvant ... See more keywords
Survival outcome of upfront surgery for clinical single-station N2 non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyac209
Abstract: BACKGROUND Pathological N2 (pN2) non-small cell lung cancer (NSCLC) is diverse; its treatment depends on the clinical N (cN) status. We aimed to determine the efficacy of upfront surgery for cN2pN2 NSCLC. METHODS The study… read more here.
Keywords: non small; surgery; survival; upfront surgery ... See more keywords
Survival outcomes of neoadjuvant therapy followed by radical resection versus upfront surgery for stage I-III pancreatic ductal adenocarcinoma: a retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgery"
DOI: 10.1097/js9.0000000000000425
Abstract: BACKGROUND Neoadjuvant therapy remains controversial in treating resectable pancreatic ductal adenocarcinoma (PDAC) patients. This study aims to assess the impact of neoadjuvant therapy on survival in patients with PDAC according to their clinical stage. METHODS… read more here.
Keywords: neoadjuvant therapy; surgery; stage iii; stage ... See more keywords
Neoadjuvant Chemotherapy with Gemcitabine and S-1 versus Upfront Surgery for Resectable Pancreatic Cancer: Results of the Randomized Phase II/III Prep-02/JSAP05 Trial.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of surgery"
DOI: 10.1097/sla.0000000000006730
Abstract: Objective: This randomized phase II/III study evaluated the superiority of neoadjuvant therapy with gemcitabine plus S-1 over upfront surgery for patients with resectable pancreatic ductal adenocarcinoma (PDAC). Background: PDAC is a leading cause of cancer… read more here.
Keywords: surgery; phase iii; neoadjuvant chemotherapy; upfront surgery ... See more keywords
Molecular Residual Disease and Recurrence in Rectal Cancer Patients Undergoing Upfront Surgery: A Prospective Cohort Study.
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DOI: 10.1097/sla.0000000000006948
Abstract: Objective: To evaluate the prognostic utility of postoperative circulating tumor DNA (ctDNA) for recurrence and treatment response in patients with rectal cancer undergoing upfront surgery. Background: ctDNA-based molecular residual disease (MRD) testing shows promise in… read more here.
Keywords: cancer; undergoing upfront; upfront surgery; rectal cancer ... See more keywords
Estimating Recurrence after Upfront Surgery in Patients with Resectable Pancreatic Ductal Adenocarcinoma by Using Pancreatic CT: Development and Validation of a Risk Score.
Sign Up to like & getrecommendations! Published in 2020 at "Radiology"
DOI: 10.1148/radiol.2020200281
Abstract: Background No preoperative model is available for predicting postsurgical prognosis of patients with resectable pancreatic ductal adenocarcinoma (PDAC). Purpose To develop and validate a preoperative risk scoring system using clinical and CT variables to predict… read more here.
Keywords: risk; recurrence; patients resectable; risk score ... See more keywords