UPLC-MS/MS method for therapeutic drug monitoring of 10 antibiotics used in intensive care units.
Sign Up to like & getrecommendations! Published in 2018 at "Drug testing and analysis"
DOI: 10.1002/dta.2253
Abstract: A large variation in the levels of different ß-lactams and other antibiotics used in critically ill patients has been documented. The aim of this study is to establish and validate a fast, ultra-performance liquid chromatography-tandem… read more here.
Keywords: uplc method; antibiotics used; drug; therapeutic drug ... See more keywords
A validated UPLC-MS/MS method for the determination of aliphatic and aromatic isocyanate exposure in human urine
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-02295-y
Abstract: 4,4′-Methylenediphenyldiisocyanate (MDI), toluenediisocyanate (2,4-TDI and 2,6-TDI), and 1,6′-hexamethylenediisocyanate (HDI) are all commonly used in the production of polyurethane-containing materials in different application areas. Workers exposed occupationally to these compounds may develop sensitization with the potential… read more here.
Keywords: uplc method; exposure; urine; method ... See more keywords
A sensitive and robust UPLC-MS/MS method for quantitation of estrogens and progestogens in human serum.
Sign Up to like & getrecommendations! Published in 2019 at "Contraception"
DOI: 10.1016/j.contraception.2018.12.010
Abstract: OBJECTIVE With the widespread use of sex-steroid hormones in contraceptives and hormone replacement therapy, there is an increasing need for reliable analytical methods. We report the development of a sensitive and robust UPLC-MS/MS method for… read more here.
Keywords: sex steroid; uplc method; quantitation; steroid hormones ... See more keywords
A rapid UPLC method with optimized sample preparation procedures for determination of furosine in milk
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Food Composition and Analysis"
DOI: 10.1016/j.jfca.2020.103571
Abstract: Abstract A rapid ultra-performance liquid chromatography (UPLC) method with simplified sample preparation procedures was developed for detection of furosine in milk. In tuning the sample preparation, nitrogen purging was not required for acid hydrolysis and… read more here.
Keywords: milk; furosine milk; uplc method; method ... See more keywords
UPLC–MS/MS method for the simultaneous quantification of three new antiretroviral drugs, dolutegravir, elvitegravir and rilpivirine, and other thirteen antiretroviral agents plus cobicistat and ritonavir boosters in human plasma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.02.002
Abstract: &NA; Rilpivirine (RPV), dolutegravir (DTG) and elvitegravir (EVG) are the latest antiretroviral drugs approved for treatment of HIV infection. Currently, poor information is currently available concerning their pharmacokinetic and pharmacodynamic properties, thus making the use… read more here.
Keywords: uplc method; antiretroviral agents; method; antiretroviral drugs ... See more keywords
A Green Approach: Optimization of the UPLC Method Using DoE Software for Concurrent Quantification of Pioglitazone and Dapagliflozin in a SNEDDS Formulation for the Treatment of Diabetes
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c04927
Abstract: Clinical trials revealed that pioglitazone (PGZ) and dapagliflozin (DGZ) not only maintain normal blood glucose levels but also reduce complications of diabetes mellitus. To meet the demand for simultaneous measurement of these drugs in fixed… read more here.
Keywords: doe software; method; dapagliflozin; pioglitazone ... See more keywords
High resolution UPLC-MS/MS method for simultaneous separation and determination of six flavonoids from semen cuscutae extract in rat plasma: application to comparative pharmacokinetic studies in normal and kidney-deficient rats
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1511556
Abstract: Abstract Semen Cuscutae, which mainly consisted of flavonoids, is a traditional Chinese herbal medicine and used for nourishing the liver and kidneys. The aim of this study was to develop a sensitive and selective UPLC-MS/MS… read more here.
Keywords: kidney deficient; rat plasma; uplc method; method simultaneous ... See more keywords
UPLC-MS/MS Method Development for Simultaneous Estimation of Diclofenac and Resveratrol-Loaded Liposomal Gel Formulation in Mice Skin Model: Application to Dermatokinetic Study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac109
Abstract: The current research work describes the development of a simple, fast, sensitive and efficient bioanalytical UPLC/MS-MS method for the simultaneous estimation of diclofenac and resveratrol in mice skin samples. Quetiapine was used as an internal… read more here.
Keywords: resveratrol; diclofenac resveratrol; gel; uplc method ... See more keywords
Simultaneous Determination of 8, 11, 12, 20-HETEs and 13 s-HODE in Paraquat and Diquat Poisoning Patients Via the UPLC-MS/MS Method.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmaf052
Abstract: An Ultra Performance Liquid Chromatography - Mass Spectrometry/Mass Spectrometry (UPL-MS/MS) method for simultaneous determination of 8, 11, 12, 20- hydroxyeicosatetraenoic acids (HETEs) and 13 s-hydroxyoctadecadienoic acid (13 s-HODE) in plasma was developed and optimized. The chromatographic separation… read more here.
Keywords: simultaneous determination; hetes hode; uplc method; poisoning patients ... See more keywords
Rapid, Validated UPLC-MS/MS Method for Determination of Glibenclamide in Rat Plasma
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2018/2569027
Abstract: Quick and specific bioanalytical methods are required for analyzing drugs in biological samples. A simple, quick, sensitive, and specific UPLC-MS/MS method was developed and validated for glibenclamide determination in plasma samples. The plasma samples were… read more here.
Keywords: glibenclamide; plasma; uplc method; rapid validated ... See more keywords
A New UPLC-MS/MS Method Validated for Quantification of Jervine in Rat Plasma and the Study of Its Pharmacokinetics in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2019/5163625
Abstract: The aim of this study was to develop an ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to assess the concentration of jervine in rat plasma and its pharmacokinetics. Diazepam was used as internal standard (IS).… read more here.
Keywords: rat plasma; uplc method; jervine; study ... See more keywords