Three Simple Properties Explain Protein Stability Change upon Mutation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00201
Abstract: Accurate prediction of protein stability upon mutation enables rational engineering of new proteins and insights into protein evolution and monogenetic diseases caused by single-point amino acid substitutions. Many tools have been developed to this aim,… read more here.
Keywords: amino acid; protein stability; model; stability ... See more keywords
Predicting protein stability changes upon mutation using a simple orientational potential
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DOI: 10.1093/bioinformatics/btad011
Abstract: Abstract Motivation Structure-based stability prediction upon mutation is crucial for protein engineering and design, and for understanding genetic diseases or drug resistance events. For this task, we adopted a simple residue-based orientational potential that considers… read more here.
Keywords: predicting protein; upon mutation; stability; orientational potential ... See more keywords
Analysis and prediction of protein folding energy changes upon mutation by element specific persistent homology
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx460
Abstract: Motivation Site directed mutagenesis is widely used to understand the structure and function of biomolecules. Computational prediction of mutation impacts on protein stability offers a fast, economical and potentially accurate alternative to laboratory mutagenesis. Most… read more here.
Keywords: protein; topology; protein stability; upon mutation ... See more keywords
SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation
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DOI: 10.1093/bioinformatics/bty635
Abstract: Motivation Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein‐protein interactions is crucial to understanding cellular signaling, the assembly and regulation of molecular complexes, the mechanisms through which… read more here.
Keywords: binding energy; upon mutation; protein protein; thermodynamics ... See more keywords
The role of data imbalance bias in the prediction of protein stability change upon mutation
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283727
Abstract: There is a controversy over what causes the low robustness of some programs for predicting protein stability change upon mutation. Some researchers suggested that low-quality data and insufficiently informative features are the primary reasons, while… read more here.
Keywords: protein stability; change upon; upon mutation; stability change ... See more keywords