Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
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DOI: 10.7554/elife.54935
Abstract: Progressive telomere shortening during lifespan is associated with restriction of cell proliferation, genome instability and aging. Apoptosis and senescence are the two major outcomes upon irreversible cellular damage. Here, we show a transition of these… read more here.
Keywords: senescence; upon telomere; apoptosis senescence; telomere shortening ... See more keywords