Downregulation of CPSF6 leads to global mRNA 3’ UTR shortening and enhanced antiviral immune responses
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DOI: 10.1371/journal.ppat.1012061
Abstract: Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3’ untranslated regions (3’ UTRs). Our previous study has revealed the global 3’ UTR shortening of host mRNAs through… read more here.
Keywords: utr shortening; mrna; immune responses; antiviral immune ... See more keywords
XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7
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DOI: 10.15252/embr.202255387
Abstract: Interferon regulatory factor (IRF) 3 and IRF7 are master regulators of type I interferon (IFN‐I)‐dependent antiviral innate immunity. Upon viral infection, a positive feedback loop is formed, wherein IRF7 promotes further induction of IFN‐I in… read more here.
Keywords: viral infection; upon viral; interferon; xaf1 ... See more keywords