Human cDC1 display constitutive activation of the UPR Sensor IRE1.
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DOI: 10.1002/eji.202149774
Abstract: The intracellular mechanisms safeguarding dendritic cell (DC) function are of biomedical interest in several immune-related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation of the unfolded protein response… read more here.
Keywords: biology; ire1; ire1 rnase; upr sensor ... See more keywords