NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.10.024
Abstract: The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However, its potential role in lymphomagenesis remains unclear. In this study, we identified an immunosuppressive state in patients with diffuse large B cell lymphoma (DLBCL),… read more here.
Keywords: lymphoma; expression contributes; upregulates expression; inflammasome upregulates ... See more keywords
Glycerol fermentation by skin bacteria generates lactic acid and upregulates the expression levels of genes associated with the skin barrier function
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14604
Abstract: Commensal bacteria play a major role in multiple skin functions by providing the first layer of defense against pathogens and maintaining the skin barrier. Staphylococcus epidermidis is one of the most common skin commensals. In… read more here.
Keywords: skin barrier; upregulates expression; expression levels; glycerol ... See more keywords
Ferric Ammonium Citrate Upregulates PD-L1 Expression through Generation of Reactive Oxygen Species
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/6284124
Abstract: Iron plays an important role in macrophage polarization by altering metabolic and redox status. However, the impact of iron on the immune status of macrophages is still controversial. In this study, we report that ferric… read more here.
Keywords: ferric ammonium; upregulates expression; oxygen; ammonium citrate ... See more keywords
P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0541
Abstract: Immunosuppressive properties of the oral anaerobic bacterium Porphyromonas gingivalis are revealed, highlighting effects of the bacterium that facilitate oral cancer progression. The data suggest that P. gingivalis, and/or signaling it mediates, can be targeted to… read more here.
Keywords: upregulates expression; infection upregulates; oral cancer; gingivalis ... See more keywords
Deletion of Annexin A1 in Mice Upregulates the Expression of Its Receptor, Fpr2/3, and Reactivity to the AnxA1 Mimetic Peptide in Platelets
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043424
Abstract: Annexin A1 (ANXA1) is an endogenous protein, which plays a central function in the modulation of inflammation. While the functions of ANXA1 and its exogenous peptidomimetics, N-Acetyl 2-26 ANXA1-derived peptide (ANXA1Ac2-26), in the modulation of… read more here.
Keywords: expression receptor; fpr2; upregulates expression; mice upregulates ... See more keywords