Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation
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DOI: 10.1002/jcb.30526
Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases with no effective cure. GGGGCC repeat expansion in C9orf72 is the most common genetic cause of both ALS and FTD. A key pathological… read more here.
Keywords: akt phosphorylation; upregulating akt; damage; mitochondrial damage ... See more keywords