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   Articles with "upregulation" as a keyword



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The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation

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recommendations! Published in 2018 at "Cancer Medicine"

DOI: 10.1002/cam4.1348

Abstract: Radiotherapy for nasopharyngeal carcinoma has been reported to cause second primary oral squamous cell carcinoma (s‐OSCC). The prognosis and pathologic characteristic of s‐OSCC are largely unknown. Bmi1 was associated with the repair of radiation‐induced DNA… read more here.

Keywords: second primary; carcinoma; bmi1 upregulation; primary oral ... See more keywords
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Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia

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recommendations! Published in 2019 at "Glia"

DOI: 10.1002/glia.23716

Abstract: Translocator protein (TSPO) expression is increased in activated glia, and has been used as a marker of neuroinflammation in PET imaging. However, the extent to which TSPO upregulation reflects a pro‐ or anti‐inflammatory phenotype remains… read more here.

Keywords: astrocytes microglia; translocator protein; inflammatory; upregulation ... See more keywords
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Upregulation of two human microRNAs which might be involved in the carcinogenesis of nasopharyngeal cancer and that are promising for biomarker development

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recommendations! Published in 2018 at "Comparative Clinical Pathology"

DOI: 10.1007/s00580-018-2721-6

Abstract: One of the biggest problems in diagnosing nasopharyngeal carcinoma (NPC) is the lack of biomarkers to detect the disease in its early stages. Thus, the exploration of biomarkers, which have the potential to be used… read more here.

Keywords: carcinogenesis; hsa mir; expression; cancer ... See more keywords

LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.

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recommendations! Published in 2021 at "Cell biology and toxicology"

DOI: 10.1007/s10565-021-09632-x

Abstract: BACKGROUND Nasopharyngeal carcinoma (NPC) has high incidence in Southern China and is derived from the mucosal epithelium of the nasopharynx. Accumulating evidence has revealed that peptidyl arginine deiminase 4 (PAD4) exerts carcinogenic effect on certain… read more here.

Keywords: pad4; upregulation; pi3k akt; apoptosis autophagy ... See more keywords
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DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.

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recommendations! Published in 2021 at "Neurochemical research"

DOI: 10.1007/s11064-021-03260-x

Abstract: Paclitaxel is a common chemotherapeutic agent in cancer treatment, while it often causes chemotherapy-induced peripheral neuropathy (CIPN), which manifested as hyperalgesia and allodynia, and its mechanism remains largely unknown. The previous study has shown that matrix metalloproteinase-2 (MMP-2)… read more here.

Keywords: sumoylation; paclitaxel induced; induced neuropathic; neuropathic pain ... See more keywords
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Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury

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recommendations! Published in 2018 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2018.04.016

Abstract: N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where… read more here.

Keywords: drg neurons; drgs; dorsal root; upregulation ... See more keywords
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Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-induced apoptosis through upregulation of Bim expression.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.03.068

Abstract: Inhibition of cathespsin S not only inhibits invasion and angiogenesis, but also induces apoptosis and autophagy in cancer cells. In present study, we revealed that pharmacological inhibitor [Z-FL-COCHO (ZFL)] of cathepsin S up-regulates pro-apoptotic protein… read more here.

Keywords: enhances oxaliplatin; inhibitor; bim expression; apoptosis ... See more keywords
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CRISPRa-mediated NEAT1 lncRNA upregulation induces formation of intact paraspeckles.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.08.158

Abstract: Long noncoding RNAs (lncRNAs) are fundamental genomic regulatory factors under various physiological and pathological conditions. A class of lncRNAs termed architectural RNAs (arcRNAs) plays an essential scaffolding role in building nuclear bodies. NEAT1 arcRNA is… read more here.

Keywords: crispra mediated; sam system; neat1 lncrna; lncrna upregulation ... See more keywords
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To die or not to die SGK1-sensitive ORAI/STIM in cell survival.

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recommendations! Published in 2018 at "Cell calcium"

DOI: 10.1016/j.ceca.2018.05.001

Abstract: The pore forming Ca2+ release activated Ca2+ channel (CRAC) isoforms ORAI1-3 and their regulators STIM1,2 accomplish store operated Ca2+ entry (SOCE). Activation of SOCE may lead to cytosolic Ca2+ oscillations, which in turn support cell… read more here.

Keywords: cell survival; sgk1 dependent; orai1 stim1; orai stim ... See more keywords
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MicroRNA profiling of second trimester maternal plasma shows upregulation of miR-195-5p in patients with gestational diabetes.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2018.06.004

Abstract: Gestational diabetes (GDM) is defined as glucose intolerance that presents during pregnancy. It increases the risk of developing diabetes later in life. Recent studies indicate the important role of microRNAs (miRNAs) in the pathogenesis of… read more here.

Keywords: gestational diabetes; mir 195; plasma; second trimester ... See more keywords
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METTL3/METTL14 Transactivation and m6A-Dependent TGF-β1 Translation in Activated Kupffer Cells

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recommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"

DOI: 10.1016/j.jcmgh.2021.05.007

Abstract: Background and Aims Transforming growth factor β1 (TGF-β1) secreted from activated Kupffer cells (KC) promotes the progression of nonalcoholic steatohepatitis (NASH) to liver fibrosis. N6-methyladenosine (m6A) RNA modification participates in various cell stress responses, yet… read more here.

Keywords: tgf; mettl3 mettl14; m6a; activated kupffer ... See more keywords