Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107027
Abstract: FoxO3a plays key roles in inflammation and autoimmunity, and the PI3K-Akt-FoxO3a pathway has been proposed to modulate diverse biological processes. The aim of the present study, using lupus murine models, was to investigate whether FoxO3a… read more here.
Keywords: mrl lpr; lpr mice; upregulation foxo3a; pi3k akt ... See more keywords
Upregulation of Foxo3a protects neurons against hypoxia-ischaemia injury
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Medical Science"
DOI: 10.5114/aoms.2020.96620
Abstract: A series of transcription factors have been profiled in ischaemic stroke. Forkhead box protein O 3a (FoxO3a), which belongs to the family of transcription factors, is characterised by a forkhead DNA-binding domain. However, the role… read more here.
Keywords: hypoxia ischaemia; upregulation foxo3a; foxo3a; foxo3a protects ... See more keywords