Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression.
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DOI: 10.1158/0008-5472.can-18-3134
Abstract: Solar ultraviolet radiation (UVR) suppresses skin immunity, which facilitates initiation of skin lesions and establishment of tumors by promoting immune evasion. It is unclear whether immune checkpoints are involved in the modulation of skin immunity… read more here.
Keywords: radiation; hmgb1; induced immune; upregulation via ... See more keywords