Specific Increase of Protein Levels by Enhancing Translation Using Antisense Oligonucleotides Targeting Upstream Open Frames.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-4310-9_9
Abstract: A number of diseases are caused by low levels of key proteins; therefore, increasing the amount of specific proteins in human bodies is of therapeutic interest. Protein expression is downregulated by some structural or sequence… read more here.
Keywords: protein; increase; translation; protein levels ... See more keywords
Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes
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DOI: 10.1038/s41598-020-73307-6
Abstract: Upstream open reading frames (uORFs) are present in the 5′-untranslated regions of many eukaryotic mRNAs, and some peptides encoded by these regions play important regulatory roles in controlling main ORF (mORF) translation. We previously developed… read more here.
Keywords: reading frames; animal genomes; upstream open; cpuorfs ... See more keywords
Upstream open reading frames mediate autophagy-related protein translation.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2059744
Abstract: Macroautophagy/autophagy, a highly conserved catabolic pathway that maintains proper cellular homeostasis is stringently regulated by numerous autophagy-related (Atg) proteins. Many studies have investigated autophagy regulation at the transcriptional level; however, relatively little is known about… read more here.
Keywords: open reading; reading frames; autophagy related; upstream open ... See more keywords
uORF4u: a tool for annotation of conserved upstream open reading frames
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DOI: 10.1093/bioinformatics/btad323
Abstract: Summary Upstream open reading frames (uORFs, encoding so-called leader peptides) can regulate translation and transcription of downstream main ORFs (mORFs) in prokaryotes and eukaryotes. However, annotation of novel functional uORFs is challenging due their short… read more here.
Keywords: reading frames; uorf4u tool; annotation; upstream open ... See more keywords
Ribo-uORF: a comprehensive data resource of upstream open reading frames (uORFs) based on ribosome profiling
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1094
Abstract: Abstract Upstream open reading frames (uORFs) are typically defined as translation sites located within the 5′ untranslated region upstream of the main protein coding sequence (CDS) of messenger RNAs (mRNAs). Although uORFs are prevalent in… read more here.
Keywords: translation; resource; ribo uorf; upstream open ... See more keywords
An upstream open reading frame (uORF) signals for cellular localization of the virulence factor implicated in pregnancy associated malaria
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky178
Abstract: Abstract Plasmodium falciparum, the causative agent of the deadliest form of human malaria, alternates expression of variable antigens, encoded by members of a multi-copy gene family named var. In var2csa, the var gene implicated in… read more here.
Keywords: associated malaria; implicated pregnancy; upstream open; localization ... See more keywords
Life cycle adapted upstream open reading frames (uORFs) in Trypanosoma congolense: A post-transcriptional approach to accurate gene regulation
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DOI: 10.1371/journal.pone.0201461
Abstract: The presented work explores the regulatory influence of upstream open reading frames (uORFs) on gene expression in Trypanosoma congolense. More than 31,000 uORFs in total were identified and characterized here. We found evidence for the… read more here.
Keywords: congolense; reading frames; upstream open; gene ... See more keywords
Common and Rare 5′UTR Variants Altering Upstream Open Reading Frames in Cardiovascular Genomics
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DOI: 10.3389/fcvm.2022.841032
Abstract: High-throughput sequencing (HTS) technologies are revolutionizing the research and molecular diagnosis landscape by allowing the exploration of millions of nucleotide sequences at an unprecedented scale. These technologies are of particular interest in the identification of… read more here.
Keywords: reading frames; common rare; upstream open; utr variants ... See more keywords
Somatic Functional Deletions of Upstream Open Reading Frame-Associated Initiation and Termination Codons in Human Cancer
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DOI: 10.3390/biomedicines9060618
Abstract: Upstream open reading frame (uORF)-mediated translational control has emerged as an important regulatory mechanism in human health and disease. However, a systematic search for cancer-associated somatic uORF mutations has not been performed. Here, we analyzed… read more here.
Keywords: termination codons; reading frame; upstream open; cancer ... See more keywords