Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
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DOI: 10.1021/acs.jmedchem.8b00408
Abstract: Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo[2,3- d]pyrimidine analogues 7-12 were synthesized and tested for selective cellular uptake by folate receptors (FRs) α and β or the proton-coupled folate transporter (PCFT) and for antitumor efficacy. Compounds 8, 9,… read more here.
Keywords: substituted pyrrolo; pyrimidine analogues; folate; pyrrolo pyrimidine ... See more keywords
Effective uptake of folate-functionalized ethionamide-loaded hybrid system: targeting alveolar macrophages.
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DOI: 10.2217/nnm-2021-0468
Abstract: Aim: To assess the targeting ability of hybrid nanosystems functionalized with folate. It also aimed to reduce stomach intolerance by substituting the oral route for parenteral delivery. Method: The nanosystems, prepared by nanoprecipitation technique, utilized a one-step… read more here.
Keywords: system; alveolar macrophages; effective uptake; targeting alveolar ... See more keywords