The inhibition of hepatic Pxr-Oatp2 pathway mediating decreased hepatic uptake of rosuvastatin in rats with high-fat diet-induced obesity.
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DOI: 10.1016/j.lfs.2020.118079
Abstract: PURPOSE Obesity affecting drug pharmacokinetics results in the risk of the therapeutic failure or toxic side effects of drugs increasing. Unfortunately, the pharmacokinetic data in obese patients still lack for majority of drugs. Therefore, our… read more here.
Keywords: rosuvastatin; pxr; hepatic uptake; obesity ... See more keywords